Epoxidation of alkenes using HOF•MeCN by a continuous flow process

被引：30

作者：

McPake, Christopher B. ^{[1
]}

Murray, Christopher B. ^{[2
]}

Sandford, Graham ^{[1
]}

机构：

[1] Univ Durham, Dept Chem, Durham DH1 3LE, England

[2] Aldermaston, AWE, Reading RG7 4PR, Berks, England

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 15期

关键词：

ELEMENTAL FLUORINE; MICROREACTORS; CHEMISTRY;

D O I：

10.1016/j.tetlet.2008.12.073

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Continuous flow methodology is described which allows the in situ generation of the highly effective oxidising agent HOF center dot MeCN from fluorine and wet acetonitrile and immediate reaction with alkenes to afford epoxides in high yield. The HOF center dot MeCN continuous flow oxidising system provides an environmentally benign process that is suitable for large scale synthesis and is atom efficient, because the only by-product is hydrogen fluoride which, in principle, could be recycled to produce fluorine by electrolysis. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved

引用

页码：1674 / 1676

页数：3

共 13 条

[1] Elemental fluorine - Part 16. Versatile thin-film gas-liquid multi-channel microreactors for effective scale-out [J].