Metformin Do we finally have an anti-aging drug?

被引：89

作者：

Anisimov, Vladimir N. ^{[1
]}

机构：

[1] NN Petrov Oncol Res Inst, Dept Carcinogenesis & Oncogerontol, St Petersburg, Russia

来源：

CELL CYCLE | 2013年 / 12卷 / 22期

关键词：

diabetes; cancer; aging; gerosuppression; geroconversion; AGE-RELATED DISEASES; EXTENDS LIFE-SPAN; HER-2/NEU TRANSGENIC MICE; FEMALE SHR MICE; CALORIC RESTRICTION; METABOLIC IMMUNODEPRESSION; CELLULAR SENESCENCE; OXIDATIVE STRESS; CANCER-PATIENTS; RHESUS-MONKEYS;

D O I：

10.4161/cc.26928

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Studies in mammals have demonstrated that hyperglycemia and hyperinsulinemia are important factors in aging and cancer. Inactivation of insulin/insulin-like signaling increases lifespan in nematodes, fruit flies, and mice. Life-prolonging effects of caloric restriction are in part due to reduction in IGF-1, insulin, and glucose levels. Antidiabetic biguanides such as metformin, which reduce hyperglycemia and hyperinsulinemia by decreasing insulin resistance, extend lifespan, and inhibit carcinogenesis in rodents. Will antidiabetic biguanides increase lifespan in humans?

引用

页码：3483 / 3489

页数：7

共 71 条

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