Kottamides A-D:: Novel bioactive imidazolone-containing alkaloids from the New Zealand ascidian Pycnoclavella kottae

被引：50

作者：

Appleton, DR

Page, MJ

Lambert, G

Berridge, MV

Copp, BR

机构：

[1] Univ Auckland, Dept Chem, Auckland, New Zealand

[2] Natl Inst Water & Atmospher Res, Wellington, New Zealand

[3] Calif State Univ Fullerton, Dept Biol Sci, Fullerton, CA 92834 USA

[4] Wellington Sch Med, Malaghan Inst Med Res, Wellington, New Zealand

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 15期

关键词：

D O I：

10.1021/jo0201427

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Kottamides A-D (1-4), novel 2,2,5-trisubstituted imidazolone-containing alkaloids, were isolated from the New Zealand endemic ascidian Pycnoclavella kottae and structurally characterized using N-15 natural abundance 2-D NMR in addition to standard spectroscopic methods. The kottamides exhibited anti-inflammatory and anti-metabolic activity as well as cytotoxicity toward tumor cell lines.

引用

页码：5402 / 5404

页数：3

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