Cancer - Gene expression in diagnosis

被引:47
作者
Berns, A [1 ]
机构
[1] Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands
关键词
D O I
10.1038/35000684
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Using DNA microarray technology, it is now possible to screen large numbers of genes for their activity, or lack of it, under various conditions. With this approach, patients with a disease known as diffuse large B-cell lymphoma can be divided into two groups which have markedly different prospects of survival. The hope is that improved treatments will follow.
引用
收藏
页码:491 / 492
页数:2
相关论文
共 9 条
  • [1] Probing lymphocyte biology by genomic-scale gene expression analysis
    Alizadeh, A
    Eisen, M
    Botstein, D
    Brown, PO
    Staudt, LM
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 1998, 18 (06) : 373 - 379
  • [2] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    Alizadeh, AA
    Eisen, MB
    Davis, RE
    Ma, C
    Lossos, IS
    Rosenwald, A
    Boldrick, JG
    Sabet, H
    Tran, T
    Yu, X
    Powell, JI
    Yang, LM
    Marti, GE
    Moore, T
    Hudson, J
    Lu, LS
    Lewis, DB
    Tibshirani, R
    Sherlock, G
    Chan, WC
    Greiner, TC
    Weisenburger, DD
    Armitage, JO
    Warnke, R
    Levy, R
    Wilson, W
    Grever, MR
    Byrd, JC
    Botstein, D
    Brown, PO
    Staudt, LM
    [J]. NATURE, 2000, 403 (6769) : 503 - 511
  • [3] Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
    Alon, U
    Barkai, N
    Notterman, DA
    Gish, K
    Ybarra, S
    Mack, D
    Levine, AJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) : 6745 - 6750
  • [4] Characterization of single-nucleotide polymorphisms in coding regions of human genes
    Cargill, M
    Altshuler, D
    Ireland, J
    Sklar, P
    Ardlie, K
    Patil, N
    Lane, CR
    Lim, EP
    Kalyanaraman, N
    Nemesh, J
    Ziaugra, L
    Friedland, L
    Rolfe, A
    Warrington, J
    Lipshutz, R
    Daley, GQ
    Lander, ES
    [J]. NATURE GENETICS, 1999, 22 (03) : 231 - 238
  • [5] Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    Golub, TR
    Slonim, DK
    Tamayo, P
    Huard, C
    Gaasenbeek, M
    Mesirov, JP
    Coller, H
    Loh, ML
    Downing, JR
    Caligiuri, MA
    Bloomfield, CD
    Lander, ES
    [J]. SCIENCE, 1999, 286 (5439) : 531 - 537
  • [6] World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee Meeting - Airlie House, Virginia, November 1997
    Harris, NL
    Jaffe, ES
    Diebold, J
    Flandrin, G
    Muller-Hermelink, HK
    Vardiman, J
    Lister, TA
    Bloomfield, CD
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (12) : 3835 - 3849
  • [7] The transcriptional program in the response of human fibroblasts to serum
    Iyer, VR
    Eisen, MB
    Ross, DT
    Schuler, G
    Moore, T
    Lee, JCF
    Trent, JM
    Staudt, LM
    Hudson, J
    Boguski, MS
    Lashkari, D
    Shalon, D
    Botstein, D
    Brown, PO
    [J]. SCIENCE, 1999, 283 (5398) : 83 - 87
  • [8] Drug target validation and identification of secondary drug target effects using DNA microarrays
    Marton, MJ
    DeRisi, JL
    Bennett, HA
    Iyer, VR
    Meyer, MR
    Roberts, CJ
    Stoughton, R
    Burchard, J
    Slade, D
    Dai, HY
    Bassett, DE
    Hartwell, LH
    Brown, PO
    Friend, SH
    [J]. NATURE MEDICINE, 1998, 4 (11) : 1293 - 1301
  • [9] Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
    Perou, CM
    Jeffrey, SS
    Van de Rijn, M
    Rees, CA
    Eisen, MB
    Ross, DT
    Pergamenschikov, A
    Williams, CF
    Zhu, SX
    Lee, JCF
    Lashkari, D
    Shalon, D
    Brown, PO
    Botstein, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) : 9212 - 9217