Synthesis and anti-inflammatory effects of xanthone derivatives

被引：101

作者：

Lin, CN ^{[1
]}

Chung, MI ^{[1
]}

Liou, SJ ^{[1
]}

Lee, TH ^{[1
]}

Wang, JP ^{[1
]}

机构：

[1] TAICHUNG VET GEN HOSP,DEPT MED RES,TAICHUNG 407,TAIWAN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1996年 / 48卷 / 05期

关键词：

D O I：

10.1111/j.2042-7158.1996.tb05969.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eighteen synthetic xanthone derivatives were tested for their inhibitory effects on the activation of mast cells and neutrophils. 1,3- and 3,5-Dihydroxyxanthone showed strong inhibitory effects on the release of beta-glucuronidase and histamine from rat peritoneal mast cells stimulated with compound 48/80. 1,6-Dihydroxyxanthone and 1,3,8-trihydroxyxanthone showed strong inhibitory effects on the release of beta-glucuronidase, and beta-glucuronidase and lysozyme, respectively, from rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP). 1,3- and 1,6-Dihydroxyxanthone, 1,3,7-trihydroxyxanthone, and 1,3,5,6-, 2,3,6,7-, and 3,4,5,6-tetrahydroxyxanthone showed potent inhibitory effects on superoxide formation of rat neutrophils stimulated with fMLP. 1,6- and 3,5-Dihydroxyxanthone showed remarkable inhibitory effects on hind-paw oedema induced by polymyxin B in normal as well as in adrenalectomized mice. These data indicated that the anti-inflammatory effect of these compounds is mediated through the suppression of chemical mediators released from mast cell and neutrophil degranulation.

引用

页码：532 / 538

页数：7

共 19 条

[1]

BERTELLI A, 1979, ARZNEIMITTEL-FORSCH, V29-1, P777

[2]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77

[3] C-13 NMR-SPECTROSCOPY OF POLYMETHOXYXANTHONES [J].