INNOVATION The Allen Brain Atlas: 5 years and beyond

被引：192

作者：

Jones, Allan R. ^{[1
]}

Overly, Caroline C. ^{[1
]}

Sunkin, Susan M. ^{[1
]}

机构：

[1] Allen Inst Brain Sci, Seattle, WA 98103 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 11期

关键词：

IN-SITU HYBRIDIZATION; ADULT-MOUSE BRAIN; CENTRAL-NERVOUS-SYSTEM; GENE-EXPRESSION ATLAS; HUMAN-GENOME-PROJECT; ALZHEIMERS-DISEASE; RAT HIPPOCAMPUS; IDENTIFICATION; MICE; TRANSCRIPTOME;

D O I：

10.1038/nrn2722

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Allen Brain Atlas, a Web-based, genome-wide atlas of gene expression in the adult mouse brain, was an experiment on a massive scale. The development of the atlas faced a combination of great technical challenges and a non-traditional open research model, and it encountered many hurdles on the path to completion and community adoption. Having overcome these challenges, it is now a fundamental tool for neuroscientists worldwide and has set the stage for the creation of other similar open resources. Nevertheless, there are many untapped opportunities for exploration.

引用

页码：821 / U78

页数：9

共 87 条

[1] Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database [J].

Alavian, Kambiz N. ;

Simon, Horst H. .

MOLECULAR NEURODEGENERATION, 2009, 4

[2]

*ALL I BRAIN SCI, 2007, COMP TOP 1000 GEN AL

[3]

*ALL I BRAIN SCI, 2006, CROSS PLATF VAL ALL

[4]

*ALL I BRAIN SCI, 2006, DAT PROD PROC ALL BR

[5]

*ALL I BRAIN SCI, 2007, NEUROBLAST US GUID A

[6]

*ALL I BRAIN SCI, 2006, ISH PLATF CONTR ALL

[7]

*ALL I BRAIN SCI, 2007, AGEA US GUID ALL BRA

[8]

*ALL I BRAIN SCI, 2006, INF DAT PROC ALL BRA

[9] BASIC LOCAL ALIGNMENT SEARCH TOOL [J].

ALTSCHUL, SF ;

GISH, W ;

MILLER, W ;

MYERS, EW ;

LIPMAN, DJ .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) :403-410

[10] ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin [J].

Andrade, Nuno ;

Komnenovic, Vukoslav ;

Blake, Sophia M. ;

Jossin, Yves ;

Howell, Brian ;

Goffinet, Andre ;

Schneider, Wolfgang J. ;

Nimpf, Johannes .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (20) :8508-8513

← 1 2 3 4 5 6 7 8 9 →