Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database

被引:7
作者
Alavian, Kambiz N. [2 ]
Simon, Horst H. [1 ]
机构
[1] Univ Heidelberg, Interdisciplinary Ctr Neurosci IZN, D-69120 Heidelberg, Germany
[2] Harvard Univ, Sch Med, Neuroregenerat Labs, McLean Hosp, Belmont, MA 02478 USA
来源
MOLECULAR NEURODEGENERATION | 2009年 / 4卷
基金
加拿大健康研究院;
关键词
GENE-EXPRESSION; TRANSCRIPTION FACTORS; SUBSTANTIA-NIGRA; MOUSE-BRAIN; VULNERABILITY; FATE;
D O I
10.1186/1750-1326-4-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Midbrain dopaminergic neurons are involved in control of emotion, motivation and motor behavior. The loss of one of the subpopulations, substantia nigra pars compacta, is the pathological hallmark of one of the most prominent neurological disorders, Parkinson's disease. Several groups have looked at the molecular identity of midbrain dopaminergic neurons and have suggested the gene expression profile of these neurons. Here, after determining the efficiency of each screen, we provide a linked database of the genes, expressed in this neuronal population, by combining and comparing the results of six previous studies and verification of expression of each gene in dopaminergic neurons, using the collection of in situ hybridization in the Allen Brain Atlas.
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页数:4
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