μ2-Alkyne dicobalt(0)hexacarbonyl complexes as carbon monoxide-releasing molecules (CO-RMs): probing the release mechanism

被引：72

作者：

Atkin, Anthony J. ^{[1
]}

Williams, Sophie ^{[1
]}

Sawle, Philip ^{[2
]}

Motterlini, Roberto ^{[2
,3
]}

Lynam, Jason M. ^{[1
]}

Fairlamb, Ian J. S. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] Northwick Pk Inst Med Res, Vasc Biol Unit, Dept Surg Res, Harrow HA1 3UJ, Middx, England

[3] Italian Inst Technol, Dept Drug Discovery & Dev, I-16163 Genoa, Italy

来源：

DALTON TRANSACTIONS | 2009年 / 19期

基金：

英国工程与自然科学研究理事会;

关键词：

COBALT-ALKYNE COMPLEXES; METAL-CARBONYLS; CELLULAR UPTAKE; CYTOTOXICITY; MODULATION; CHEMISTRY;

D O I：

10.1039/b904627p

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first carbon monoxide-releasing molecules (CO-RMs) based on mu(2)-alkyne dicobalt(0)hexacarbonyl complexes are reported. The alkyne substituents significantly affect the rate of CO-release, cytotoxicity and cell viability. Mechanistic studies provide insight into the CO-RM activation pathways.

引用

页码：3653 / 3656

页数：4

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