Duplicating dangerously: Linking centrosome duplication and aneuploidy

被引：71

作者：

Doxsey, S ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Med, Worcester, MA 01605 USA

来源：

MOLECULAR CELL | 2002年 / 10卷 / 03期

关键词：

D O I：

10.1016/S1097-2765(02)00654-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Centrosomes are far more fascinating than the first explorers of this organelle a century ago could ever have imagined. Recent evidence indicates that deregulation of centrosome duplication affects centrosome number and promotes aneuploidy, features characteristic of human tumors.

引用

页码：439 / 440

页数：2

共 9 条

[1] CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells [J].

Chen, ZH ;

Indjeian, VB ;

McManus, M ;

Wang, LY ;

Dynlacht, BD .

DEVELOPMENTAL CELL, 2002, 3 (03) :339-350

[2] The mouse Mps1p-like kinase regulates centrosome duplication [J].

Fisk, HA ;

Winey, M .

CELL, 2001, 106 (01) :95-104

[3] Modelling the molecular circuitry of cancer [J].

Hahn, WC ;

Weinberg, RA .

NATURE REVIEWS CANCER, 2002, 2 (05) :331-341

[4] It takes two to tango: understanding how centrosome duplication is regulated throughout the cell cycle [J].

Hinchcliffe, EH ;

Sluder, G .

GENES & DEVELOPMENT, 2001, 15 (10) :1167-1181

[5] Centrosome amplification drives chromosomal instability in breast tumor development [J].

Lingle, WL ;

Barrett, SL ;

Negron, VC ;

D'Assoro, AB ;

Boeneman, K ;

Liu, WG ;

Whitehead, CM ;

Reynolds, C ;

Salisbury, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :1978-1983

[6] Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells [J].

Meraldi, P ;

Honda, R ;

Nigg, EA .

EMBO JOURNAL, 2002, 21 (04) :483-492

[7] Nucleophosmin/B23 is a target of CDK2/Cyclin E in centrosome duplication [J].

Okuda, M ;

Horn, HF ;

Tarapore, P ;

Tokuyama, Y ;

Smulian, AG ;

Chan, PK ;

Knudsen, ES ;

Hofmann, IA ;

Snyder, JD ;

Bove, KE ;

Fukasawa, K .

CELL, 2000, 103 (01) :127-140

[8] The mitotic machinery as a source of genetic instability in cancer [J].

Pihan, GA ;

Doxsey, SJ .

SEMINARS IN CANCER BIOLOGY, 1999, 9 (04) :289-302

[9] Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication [J].

Stucke, VM ;

Silljé, HHW ;

Arnaud, L ;

Nigg, EA .

EMBO JOURNAL, 2002, 21 (07) :1723-1732

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