Caveolin-1 is essential for liver regeneration

被引：241

作者：

Fernandez, Manuel A.

Albor, Cecilia

Ingelmo-Torres, Mercedes

Nixon, Susan J.

Ferguson, Charles

Kurzchalia, Teymuras

Tebar, Francesc

Enrich, Carlos

Parton, Robert G. ^{[1
]}

Pol, Albert

机构：

[1] Univ Queensland, Inst Mol Biosci, Ctr Microscopy & Microanal, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia

[3] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Fac Med, Dept Cellular Biol, E-08036 Barcelona, Spain

[4] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

来源：

SCIENCE | 2006年 / 313卷 / 5793期

关键词：

D O I：

10.1126/science.1130773

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 gene - disrupted mice (cav1(-/-) mice) exhibited impaired liver regeneration and low survival after a partial hepatectomy. Hepatocytes showed dramatically reduced lipid droplet accumulation and did not advance through the cell division cycle. Treatment of cav1(-/-) mice with glucose ( which is a predominant energy substrate when compared to lipids) drastically increased survival and reestablished progression of the cell cycle. Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury.

引用

页码：1628 / 1632

页数：5

共 16 条

[1]

Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver [J].