Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development

被引:141
作者
Van Eck, M [1 ]
Bos, IST [1 ]
Hildebrand, RB [1 ]
Van Rij, BT [1 ]
Van Berkel, TJC [1 ]
机构
[1] Leiden Univ, Gorlaeus Labs, Div Biopharmaceut, Leiden Amsterdam Ctr Drug Res, NL-2333 CC Leiden, Netherlands
关键词
D O I
10.1016/S0002-9440(10)63341-X
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The function of scavenger receptor class B, type I (SR-BI) in the liver as a high-density Upoprotein receptor that promotes the selective uptake of cholesteryl esters is well defined. its role in macrophages, however, is primarily unknown, because it functions in the uptake of (modified) lipoproteins as well as the secretion of cholesterol to high-density lipoproteins. In this study, the biological role of SR-BI on bone marrow-derived cells, including macrophages, in lipid metabolism and atherosclerosis was assessed by selective disruption of SR-BI in hone marrow in two established models of atherosclerosis: low-density lipoprotein (LDL) receptor-deficient mice that develop extensive atherosclerosis on a Western-type diet and wild-type mice that develop fatty streak lesions when fed a high-cholesterol diet containing 0.5% cholate. The presence of SR-BI in bone marrow-derived cells in LDLr-/- mice decreased lesion development after 9 and 12 weeks of Western-type diet feeding, indicating that macrophage SR-BI protects against lesion development. At 6 weeks, no significant effect of SR-BI in bone marrow-derived cells on lesion development was observed. Interestingly, after only 4 weeks of Western-type diet feeding of transplanted LDLr-/- mice and in wild-type mice on a high-cholesterol/cholate diet, the presence of SR-BI in bone marrow-derived cells increased the development of small fatty streak lesions. It thus appears that, depending on the stage of atherosclerotic lesion development, SR-BI in bone marrow-derived cells is either pro-atherogenic or anti-atherogenic, indicating a unique dual role in the pathogenesis of atherosclerosis.
引用
收藏
页码:785 / 794
页数:10
相关论文
共 57 条
[41]   Transport of lipids from high and low density lipoproteins via scavenger receptor-BI [J].
Stangl, H ;
Hyatt, M ;
Hobbs, HH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (46) :32692-32698
[42]   Scavenger receptor, class B, type I-dependent stimulation of cholesterol esterification by high density lipoproteins, low density lipoproteins, and nonlipoprotein cholesterol [J].
Stangl, H ;
Cao, GQ ;
Wyne, KL ;
Hobbs, HH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (47) :31002-31008
[43]   Regulation and mechanisms of macrophage cholesterol efflux [J].
Tall, AR ;
Costet, P ;
Wang, N .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (07) :899-904
[44]   The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism [J].
Trigatti, B ;
Rigotti, A ;
Krieger, M .
CURRENT OPINION IN LIPIDOLOGY, 2000, 11 (02) :123-131
[45]   Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology [J].
Trigatti, B ;
Rayburn, H ;
Viñals, M ;
Braun, A ;
Miettinen, H ;
Penman, M ;
Hertz, M ;
Schrenzel, M ;
Amigo, L ;
Rigotti, A ;
Krieger, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) :9322-9327
[46]   Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics [J].
Ueda, Y ;
Gong, E ;
Royer, L ;
Cooper, PN ;
Francone, OL ;
Rubin, EM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (27) :20368-20373
[47]   Accelerated atherosclerosis in C57B1/6 mice transplanted with ApoE-deficient bone marrow [J].
Van Eck, M ;
Herijgers, N ;
Vidgeon-Hart, M ;
Pearce, NJ ;
Hoogerbrugge, PM ;
Groot, PHE ;
Van Berkel, TJC .
ATHEROSCLEROSIS, 2000, 150 (01) :71-80
[48]   Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver [J].
Van Eck, M ;
Twisk, J ;
Hoekstra, M ;
Van Rij, BT ;
Van der Lans, CAC ;
Bos, IST ;
Kruijt, JK ;
Kuipers, F ;
Van Berkel, TJC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (26) :23699-23705
[49]   Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues [J].
Van Eck, M ;
Bos, IST ;
Kaminski, WE ;
Orsó, E ;
Rothe, G ;
Twisk, J ;
Böttcher, A ;
Van Amersfoort, ES ;
Christiansen-Weber, TA ;
Fung-Leung, WP ;
Van Berkel, TJC ;
Schmitz, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (09) :6298-6303
[50]   Cholesterol efflux from macrophages and other cells [J].
vonEckardstein, A .
CURRENT OPINION IN LIPIDOLOGY, 1996, 7 (05) :308-319