CELLULAR MECHANISM FOR TARGETING HETEROCHROMATIN FORMATION IN DROSOPHILA

被引：48

作者：

Eissenberg, Joel C. ^{[1
]}

Reuter, Gunter ^{[2
]}

机构：

[1] St Louis Univ, Sch Med, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

[2] Univ Halle Wittenberg, Inst Biol, Halle, Germany

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 273 | 2009年 / 273卷

关键词：

Drosophila; Heterochromatin; Position-effect variegation; Chromatin; POSITION-EFFECT VARIEGATION; MELANOGASTER POLYTENE CHROMOSOMES; HISTONE H3S10 KINASE; SALIVARY-GLAND CHROMOCENTER; H3; LYSINE-9; METHYLATION; CHROMATIN-STRUCTURE; PERICENTRIC HETEROCHROMATIN; GENE-EXPRESSION; DNA-SEQUENCES; HP1; BINDING;

D O I：

10.1016/S1937-6448(08)01801-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Near the end of their 1990 historical perspective article "60 Years of Mystery," Spradling and Karpen (1990) observe: "Recent progress in understanding variegation at the molecular level has encouraged some workers to conclude that the heterochromatization model is essentially correct and that position-effect variegation can now join the mainstream of molecular biology." In the 18 years since those words were written, heterochromatin and its associated position effects have indeed joined the mainstream of molecular biology. Here, we review the findings that led to our current understanding of heterochromatin formation in Drosophila and the mechanistic insights into heterochromatin structural and functional properties gained through molecular genetics and cytology.

引用

页码：1 / +

页数：48

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