pK(a) determination of nimesulide in methanol-water mixtures by potentiometric titrations

被引：48

作者：

Fallavena, PRB

Schapoval, EES

机构：

[1] Fed. University of Rio Grande do Sul, Faculty of Pharmacy, Post-Graduate Course in Pharmacy, Porto Alegre, Rio Grande do Sul

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1997年 / 158卷 / 01期

关键词：

pK(a) determination; nimesulide; dissociation constants;

D O I：

10.1016/S0378-5173(97)00221-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pK(a) of nimesulide was determined by potentiometric titrations of a series of semisqueous nimesulide solutions of known concentration and 34.47-60 Wt% of methanol in water, with a glass electrode, using a pH meter calibrated by means of standard aqueous buffer solutions. The estimated pK(a) corresponding to a zero value of methanol was obtained from Yasuda-Shedlovisky plots and the pK(a) value was 6.46. (C) 1997 Elsevier Science B.V.

引用

页码：109 / 112

页数：4

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