Helicobacter pylori and gastroesophageal reflux disease: a review of this intriguing relationship

被引：25

作者：

Almada de Souza, R. Canzi ^{[1
]}

Cavalcante Lima, Jose Hermenio ^{[2
]}

机构：

[1] Univ Fed Parana, Dept Clin Med, Div Gastroenterol, BR-80030200 Curitiba, Parana, Brazil

[2] Univ Fed Parana, Dept Clin Pathol, BR-80030200 Curitiba, Parana, Brazil

来源：

DISEASES OF THE ESOPHAGUS | 2009年 / 22卷 / 03期

关键词：

gastroesophageal reflux; helicobacter infection; helicobacter pylori; immunology; REGULATORY T-CELLS; NF-KAPPA-B; GASTRIC-CANCER; ATROPHIC GASTRITIS; BARRETTS-ESOPHAGUS; CORPUS GASTRITIS; MONGOLIAN GERBILS; EPITHELIAL-CELLS; ACID-SECRETION; DUODENAL-ULCER;

D O I：

10.1111/j.1442-2050.2008.00911.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A possible association between gastroesophageal reflux disease (GERD) and Helicobacter pylori (H. pylori) infection has been the subject of study and debate in recent years. This review discusses the pathophysiological and immunological mechanisms implicated in this relationship. Although gastric secretion in the majority of H. pylori-infected individuals is unaltered, this review considers how the bacteria may interfere with gastric acid production and what role it may play in GERD. We also identify the epidemiological evidence that confirms that GERD develops after the infection has been eradicated. Lastly, we clarify how the host's immune response and bacterial virulence factors interfere with this relationship, explaining the highly conflicting results in the literature.

引用

页码：256 / 263

页数：8

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