Antiatherogenic effect of grape flavonoids in an ex vivo model

被引：15

作者：

Nikitina, N. A. ^{[1
]}

Sobenin, I. A.

Myasoedova, V. A.

Korennaya, V. V.

Mel'nichenko, A. A.

Khalilov, E. A.

Orekhov, A. N.

机构：

[1] Minist Hlth Russian Federat, Inst Physicochem Med, Moscow, Russia

[2] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 109801, Russia

[3] Minist Hlth Russian Federat, Cardiol Res Ctr, Inst Expt Cardiol, Moscow, Russia

[4] Russian Acad Nat Sci, Inst Atherosclerosis, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 06期

关键词：

phytoestrogens; atherosclerosis; postclimacteric period; human monocyte culture; intracellular accumulation of cholesterol;

D O I：

10.1007/s10517-006-0260-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

The effects of grape phytoestrogens on cholesterol accumulation were studied in primary culture of human blood monocytes incubated with blood serum from postmenopausal women obtained before and 2, 4, and 6 h after single intake of plant components of grapes. Phytoestrogens from grape seeds, pressed out grapes, and fermented grape ridges prevent cholesterol accumulation in cells and can be regarded as prospective components for the development of natural preparations for the prevention of atherosclerosis in postmenopausal women.

引用

页码：712 / 715

页数：4

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