A Synthetic Lectin for β-Glucosyl

被引：93

作者：

Barwell, Nicholas P. ^{[1
]}

Crump, Matthew P. ^{[1
]}

Davis, Anthony P. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 41期

基金：

英国工程与自然科学研究理事会;

关键词：

biomimetics; carbohydrates; molecular recognition; receptors; supramolecular chemistry; CARBOHYDRATE-RECOGNITION; RECEPTORS; BINDING; WATER; BIOSENSORS; PROTEIN;

D O I：

10.1002/anie.200903104

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Evolving tastes: Addition of alkoxy groups (green; see picture) to macrotricyclic carbohydrate receptors yields improved affinities and new selectivities. Notably, the propoxy-substituted receptor shows a strong preference for β-glucosyl. Glucose is bound both in water and reconstituted blood plasma, which holds promise for applications in blood glucose monitoring. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7673 / 7676

页数：4

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