Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol

被引：468

作者：

Karki, Shyam ^{[1
,2
]}

Friscic, Tomislav ^{[1
,2
]}

Fabian, Laszlo ^{[3
]}

Laity, Peter R. ^{[4
,5
]}

Day, Graeme M. ^{[1
,2
]}

Jones, William ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Cambridge, Pfizer Inst Pharmaceut Mat Sci, Cambridge CB2 1EW, England

[3] Cambridge Crystallog Data Ctr, Cambridge CB2 1EZ, England

[4] Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 3QZ, England

[5] Univ Cambridge, Pfizer Inst Pharmaceut Mat Sci, Cambridge CB2 3QZ, England

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 38-39期

关键词：

X-RAY-DIFFRACTION; ORTHORHOMBIC POLYMORPH; VARIABLE-TEMPERATURE; PURE PARACETAMOL; STABILITY; RITONAVIR; PRESSURE; SOLVENT; RULE;

D O I：

10.1002/adma.200900533

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.

引用

页码：3905 / +

页数：6

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