Cell therapy for intervertebral disc herniation and degenerative disc disease: clinical trials

被引：85

作者：

Schol, Jordy ^{[1
]}

Sakai, Daisuke ^{[1
]}

机构：

[1] Tokai Univ, Sch Med, Dept Orthopaed Surg, 143 Shimokasya, Isehara, Kanagawa 2591143, Japan

来源：

INTERNATIONAL ORTHOPAEDICS | 2019年 / 43卷 / 04期

关键词：

Clinical trials; Cell therapy; Regenerative medicine; Intervertebral disc; Degeneration; MESENCHYMAL STEM-CELLS; BONE-MARROW-CELLS; LOW-BACK-PAIN; CHONDROCYTE TRANSPLANTATION; INTRADISCAL INJECTION; MAGNETIC-RESONANCE; LUMBAR FUSION; STROMAL CELLS; REPAIR; MODEL;

D O I：

10.1007/s00264-018-4223-1

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Low back pain is the primary cause of disability and is highly associated with progression of intervertebral disc degeneration. Current treatment options are limited and fail to address the origin of the problem. New advancements in cellular therapies might offer novel and potent strategies for low back pain patients. In this review, we summarize and discuss the contemporary status of in-human trials investigating cellular transplantation for treatment of low back pain. We aim to highlight current trends, shortcomings, and hurdles for effective clinical trials and consecutive commercialization.

引用

页码：1011 / 1025

页数：15

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