Development and applications of a practical continuous flow microwave cell

被引：92

作者：

Wilson, NS ^{[1
]}

Sarko, CR ^{[1
]}

Roth, GP ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Dept Med Chem, Ridgefield, CT 06877 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 03期

关键词：

D O I：

10.1021/op034181b

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of synthetic transformations were successfully and safely scaled up to multigram quantities using focused microwave irradiation with a continuous flow reaction cell that was developed in-house and which can be easily adapted to commercially available instrumentation. The representative reactions that were investigated included aromatic nucleophilic substitution (SNAr),. esterification, and the Suzuki cross-coupling reaction. In general, the product yields were equivalent to or greater than those run under conventional thermal heating conditions.

引用

页码：535 / 538

页数：4

共 16 条

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