Cost-effectiveness of Private Umbilical Cord Blood Banking

被引：27

作者：

Kaimal, Anjali J. ^{[1
]}

Smith, Catherine C.

Laros, Russell K., Jr.

Caughey, Aaron B.

Cheng, Yvonne W.

机构：

[1] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Div Maternal Fetal Med, San Francisco, CA 94143 USA

来源：

OBSTETRICS AND GYNECOLOGY | 2009年 / 114卷 / 04期

关键词：

VERSUS-HOST-DISEASE; BONE-MARROW; STEM-CELLS; TRANSPLANTATION; CHILDREN; COLLECTION; LEUKEMIA; DONORS; RISK; OUTCOMES;

D O I：

10.1097/AOG.0b013e3181b8fc0d

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: To investigate the cost-effectiveness of private umbilical cord blood banking. METHODS: A decision-analytic model was designed comparing private umbilical cord blood banking with no umbilical cord blood banking. Baseline assumptions included a cost of $3,620 for umbilical cord blood banking and storage for 20 years, a 0.04% chance of requiring an autologous stem cell transplant, a 0.07% chance of a sibling requiring an allogenic stem cell transplant, and a 50% reduction in risk of graft-versus-host disease if a sibling uses banked umbilical cord blood. RESULTS: Private cord blood banking is not cost-effective because it cost an additional $1,374,246 per life-year gained. In sensitivity analysis, if the cost of umbilical cord blood banking is less than $262 or the likelihood of a child needing a stem cell transplant is greater than 1 in 110, private umbilical cord blood banking becomes cost-effective. CONCLUSION: Currently, private umbilical cord blood banking is cost-effective only for children with a very high likelihood of needing a stem cell transplant. Patients considering private blood banking should be informed of the remote likelihood that a unit will be used for a child or another family member. (Obstet Gynecol 2009;114:848-55)

引用

页码：848 / 855

页数：8

共 34 条

[1]

[Anonymous], 1996, Cost-effectiveness in health and medicine

[2] Collection and preservation of cord blood for personal use [J].

Ballen, Karen K. ;

Barker, Juliet N. ;

Stewart, Susan K. ;

Greene, Michael F. ;

Lane, Thomas A. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2008, 14 (03) :356-363

[3] Searching for unrelated donor hematopoietic stem cells: Availability and speed of umbilical cord blood versus bone marrow [J].

Barker, JN ;

Krepski, TP ;

DeFor, TE ;

Davies, SM ;

Wagner, JE ;

Weisdorf, DJ .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2002, 8 (05) :257-260

[4] Probability of finding HLA-mismatched related or unrelated marrow or cord blood donors [J].

Beatty, PG ;

Boucher, KM ;

Mori, M ;

Milford, EL .

HUMAN IMMUNOLOGY, 2000, 61 (08) :834-840

[5] Public cord blood banking may play an important role in the emergence of unrelated transplant in developing countries [J].

Boo, Michael .

TRANSFUSION, 2008, 48 (02) :207-208

[6] Umbilical cord blood transplantation and banking [J].

Brunstein, CG ;

Wagner, JE .

ANNUAL REVIEW OF MEDICINE, 2006, 57 :403-417

[7] Cord blood banking for potential future transplantation [J].

Cairo, Mitchell S. ;

Kurtzberg, Joanne ;

Lubin, Bertram H. ;

Shearer, William T. ;

Feig, Stephen A. ;

Corrigan, James J. ;

Gamis, Alan S. ;

Kodish, Eric D. ;

Lane, Peter A. ;

Hutter, John J. ;

Berkow, Roger L. ;

Cairo, Mitchell S. ;

Lubin, Naomi L. ;

Forman, Edwin N. ;

Laskosz, Laura ;

Williams, Paul V. ;

Chipps, Bradley E. ;

Fasano, Mary B. ;

Lester, Mitchell R. ;

Sicherer, Scott H. ;

Virant, Frank S. ;

Bahna, Sami L. ;

Welch, Michael J. ;

Rachelefsky, Gary S. ;

Mahr, Todd A. ;

Kanda, Pamela T. .

PEDIATRICS, 2007, 119 (01) :165-170

[8] The London Cord Blood Bank: analysis of banking and transplantation outcome [J].

Davey, S ;

Armitage, S ;

Rocha, V ;

Garnier, F ;

Brown, J ;

Brown, CJ ;

Warwick, R ;

Fehily, D ;

Watt, S ;

Gluckman, E ;

Vora, A ;

Contreras, M ;

Navarrete, CV .

BRITISH JOURNAL OF HAEMATOLOGY, 2004, 125 (03) :358-365

[9] A decade of direct-to-consumer advertising of prescription drugs [J].

Donohue, Julie M. ;

Cevasco, Marisa ;

Rosenthal, Meredith B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (07) :673-681

[10] Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study [J].

Eapen, Mary ;

Rubinstein, Pablo ;

Zhang, Mei-Jie ;

Stevens, Cladd ;

Kurtzberg, Joanne ;

Scaradavou, Andromachi ;

Loberiza, Fausto R. ;

Champlin, Richard E. ;

Klein, John P. ;

Horowitz, Mary M. ;

Wagner, John E. .

LANCET, 2007, 369 (9577) :1947-1954

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