Reversing the kinesin ratchet - a diverting tail

被引:10
作者
Cross, RA
机构
[1] Molecular Motors Group,
[2] Marie Curie Research Institute,undefined
关键词
D O I
10.1038/37864
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Motor proteins such as kinesin help to haul cellular cargo along microtubules, and they are mechanically programmed to move in one direction only -- towards either the rapidly growing plus ends, or the static minus ends. But what determines the direction of movement? To address this question, a chimaera has been created in which the head of a minus-end kinesin is attached to the tail ofa plus-end kinesin. And the chimaera moves in the opposite direction to the minus-end heads.
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页码:15 / 16
页数:2
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