Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

被引：2422

作者：

Dubois, Bruno ^{[1
,2
]}

Feldman, Howard H. ^{[1
,3
,4
]}

Jacova, Claudia

Hampel, Harald ^{[2
]}

Molinuevo, Jose Luis ^{[5
,6
]}

Blennow, Kaj ^{[7
]}

Dekosky, Steven T. ^{[8
]}

Gauthier, Serge ^{[9
]}

Selkoe, Dennis ^{[10
]}

Bateman, Randall ^{[11
]}

Cappa, Stefano ^{[12
,13
]}

Crutch, Sebastian ^{[14
,15
]}

Engelborghs, Sebastiaan ^{[16
,17
,18
]}

Frisoni, Giovanni B. ^{[19
,20
,21
,22
]}

Fox, Nick C. ^{[14
]}

Galasko, Douglas ^{[23
]}

Habert, Marie-Odile ^{[24
,25
]}

Jicha, Gregory A. ^{[26
]}

Nordberg, Agneta ^{[27
]}

Pasquier, Florence ^{[28
,29
]}

Rabinovici, Gil ^{[30
]}

Robert, Philippe ^{[31
]}

Rowe, Christopher ^{[32
,33
]}

Salloway, Stephen ^{[34
]}

Sarazin, Marie ^{[35
,36
]}

Epelbaum, Stephane ^{[1
,2
]}

de Souza, Leonardo C. ^{[1
,2
,37
]}

Vellas, Bruno ^{[38
]}

Visser, Pieter J. ^{[39
,40
,41
]}

Schneider, Lon ^{[42
]}

Stern, Yaakov ^{[43
]}

Scheltens, Philip ^{[44
]}

Cummings, Jeffrey L. ^{[45
]}

机构：

[1] Inst Cerveau & Moelle Epiniere, Ctr Malad Cognit & Comportement, Paris, France

[2] Univ Paris 06, AP HP, Hop Salpetriere, Paris, France

[3] Univ British Columbia, Div Neurol, Vancouver, BC V5Z 1M9, Canada

[4] Vancouver Coastal Hlth, Vancouver, BC, Canada

[5] Hosp Clin Univ, IDIBAPS, Alzheimers Dis & Other Cognit Disorders Unit, Neurol Serv, Barcelona, Spain

[6] Fundacio Pasqual Maragall, BarcelonaBeta Brain Res Ctr, Barcelona, Spain

[7] Univ Gothenburg, Sahlgrenska Univ Hosp, Sahlgrenska Acad,Clin Neurochem Lab, Inst Neurosci & Physiol,Dept Psychiat & Neurochem, Molndal, Sweden

[8] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[9] Douglas Hosp, McGill Ctr Studies Aging, Montreal, PQ, Canada

[10] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

[11] Washington Univ, Sch Med, St Louis, MO USA

[12] Univ Vita Salute San Raffaele, Milan, Italy

[13] Dept Clin Neurosci Cognit Neurorehabil, Milan, Italy

[14] UCL, Dementia Res Ctr, Inst Neurol, Dept Neurodegenerat, London, England

[15] Natl Hosp, Dementia Res Ctr, London WC1N 3BG, England

[16] Hosp Network Antwerp ZNA, Dept Neurol, Middelheim & Hoge Beuken, Antwerp, Belgium

[17] Hosp Network Antwerp ZNA, Memory Clin, Antwerp, Belgium

[18] Univ Antwerp, Reference Ctr Biol Markers Dementia, Inst Born Bunge, B-2020 Antwerp, Belgium

[19] Hop Univ, Geneva, Switzerland

[20] Univ Geneva, Geneva, Switzerland

[21] IRCCS Fatebenefratelli, Brescia, Italy

[22] HUG Belle Idee, Chene Bourg, France

[23] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA

[24] INSERM, UMR, Paris, France

[25] Grp Hosp Pitie Salpetriere, AP HP, Serv Med Nucl, Paris, France

[26] Univ Kentucky, Alzheimers Dis Ctr, Lexington, KY USA

[27] Karolinska Univ Hosp Huddinge, Karolinska Inst, Alzheimer Neurobiol Ctr, Stockholm, Sweden

[28] Univ Lille Nord France, Lille, France

[29] CHRU, Hop Roger Salengro, Clin Neurolog, Lille, France

[30] Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA

[31] Univ Nice, UNSA, CHU, EA CoBTeK & Memory Ctr, Nice, France

[32] Austin Hlth, Dept Nucl Med, Melbourne, Vic, Australia

[33] Austin Hlth, Ctr PET, Melbourne, Vic, Australia

[34] Brown Univ, Butler Hosp, Warren Alpert Med Sch, Dept Neurol & Psychiat,Neurol & Mem Aging Program, Providence, RI 02912 USA

[35] Ctr Hosp St Anne, Paris, France

[36] Univ Paris 05, Paris, France

[37] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG, Brazil

[38] Univ Toulouse 3, F-31062 Toulouse, France

[39] Maastricht Univ, Med Ctr Maastricht, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci,Dept Psychiat & Neurop, Amsterdam, Netherlands

[40] Dept Neurol, Amsterdam, Netherlands

[41] Alzheimer Ctr, Amsterdam, Netherlands

[42] USC, Keck Sch Med, Dept Psychiat Neurol & Gerontol, Los Angeles, CA USA

[43] Presbyterian Hosp, Taub Inst, Cognit Neurosci Div, New York, NY USA

[44] Vrije Univ Amsterdam, Alzheimer Ctr, Med Ctr, Amsterdam, Netherlands

[45] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA

来源：

LANCET NEUROLOGY | 2014年 / 13卷 / 06期

关键词：

MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID BIOMARKERS; POSITRON-EMISSION-TOMOGRAPHY; TEMPORAL-LOBE DYSFUNCTION; BETA-AMYLOID; 1-42; BRAIN GLUCOSE-METABOLISM; GENOME-WIDE ASSOCIATION; VERBAL-LEARNING TEST; TERM-MEMORY BINDING; CSF BIOMARKERS;

D O I：

10.1016/S1474-4422(14)70090-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fiuorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the predinical states of AD.

引用

页码：614 / 629

页数：16

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