Resource competition as a mechanism for B cell homeostasis

被引：69

作者：

McLean, AR

Rosado, MM

Agenes, F

Vasconcellos, R

Freitas, AA

机构：

[1] INST PASTEUR, UNITE IMMUNOBIOL, F-75724 PARIS 15, FRANCE

[2] UNIV OXFORD, DEPT ZOOL, OXFORD OX1 3PS, ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 11期

关键词：

ANTIGEN PRESENTATION; POSITIVE SELECTION; TRANSGENIC MICE; T-CELLS; REPERTOIRES; EXPRESSION; SURVIVAL; KINETICS; DEATH; MODEL;

D O I：

10.1073/pnas.94.11.5792

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cellular competition for survival signals offers a cogent and appealing mechanism for the maintenance of cellular homeostasis [Raff, M, C, (1992) Nature (London) 356, 397-400], We present a theoretical and experimental investigation of the role of competition for resources in the regulation of peripheral B cell numbers, We use formal ecological competition theory, mathematical models of interspecific competition, and competitive repopulation experiments to show that B cells must compete to persist in the periphery and that antigen forms a part of the resources over which B cells compete.

引用

页码：5792 / 5797

页数：6

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