Novel envelope determinants for CCR3 use by human immunodeficiency virus

被引：16

作者：

Aasa-Chapman, Marlen M. I.

Seymour, Craig R.

Williams, Ian

McKnight, Aine

机构：

[1] UCL, Wohl Virion Ctr, Div Infect & Immun, London, England

[2] UCL, Ctr Sexual Hlth & HIV Res, London, England

来源：

JOURNAL OF VIROLOGY | 2006年 / 80卷 / 21期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1128/JVI.01030-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus type 1 can generally use CCR3 and CCR5 for cell entry. We show that envelopes with novel phenotypes arise during "coreceptor. switch": one loses the ability to use CCR3 (R5-only phenotype), and another gains use of CXCR4 in addition to CCR5 and CCR3 (R3/R5/X4-using phenotype). The envelope determinants for CCR3 use mapped to three amino acids. One, N356 in conserved region 3, is a potential glycosylation site and has not previously been associated with coreceptor use. The other two, R440 and N448 in conserved region 4, are proximal to but distinct from residues already identified as being important for CCR5 binding.

引用

收藏

页码：10884 / 10889

页数：6

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