Getting the Bugs out of the Immune System: Do Bacterial Microbiota "Fix" Intestinal T Cell Responses?

被引：41

作者：

Chow, Janet ^{[1
]}

Mazmanian, Sarkis K. ^{[1
]}

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

CELL HOST & MICROBE | 2009年 / 5卷 / 01期

关键词：

LAMINA PROPRIA; HELPER-CELLS; DIFFERENTIATION; T(H)17; GUT; EXPRESSION; DIRECTS; DRIVES;

D O I：

10.1016/j.chom.2008.12.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Proinflammatory T helper 17 (Th17) cells control infections caused by microbial pathogens. Surprisingly, several recent reports now reveal that symbiotic gut bacteria modulate Th17 cell differentiation and function in the gastrointestinal tract. As various autoimmune and allergic disorders are mediated by uncontrolled T cell responses, immune regulation by the microbiota may have direct implications for human health.

引用

收藏

页码：8 / 12

页数：5

相关论文

共 19 条

[1]

ATP drives lamina propria TH17 cell differentiation [J].

Atarashi, Koji ;

Nishimura, Junichi ;

Shima, Tatsuichiro ;

Umesaki, Yoshinori ;

Yamamoto, Masahiro ;

Onoue, Masaharu ;

Yagita, Hideo ;

Ishii, Naoto ;

Evans, Richard ;

Honda, Kenya ;

Takeda, Kiyoshi .

NATURE, 2008, 455 (7214) :808-U10

[2]

Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[3]

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].

Bettelli, E ;

Carrier, YJ ;

Gao, WD ;

Korn, T ;

Strom, TB ;

Oukka, M ;

Weiner, HL ;

Kuchroo, VK .

NATURE, 2006, 441 (7090) :235-238

[4]

Regulatory T cell lineage specification by the forkhead transcription factor FoxP3 [J].

Fontenot, JD ;

Rasmussen, JP ;

Williams, LM ;

Dooley, JL ;

Farr, AG ;

Rudensky, AY .

IMMUNITY, 2005, 22 (03) :329-341

[5]

A comparative study between T regulatory type 1 and CD4+CD25+ T cells in the control of inflammation [J].

Foussat, A ;

Cottrez, F ;

Brun, V ;

Fournier, N ;

Breittmayer, JP ;

Groux, H .

JOURNAL OF IMMUNOLOGY, 2003, 171 (10) :5018-5026

[6]

Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses [J].

Hall, Jason A. ;

Bouladoux, Nicolas ;

Sun, Cheng Ming ;

Wohlfert, Elizabeth A. ;

Blank, Rebecca B. ;

Zhu, Qing ;

Grigg, Michael E. ;

Berzofsky, Jay A. ;

Belkaid, Yasmine .

IMMUNITY, 2008, 29 (04) :637-649

[7]

Commensal host-bacterial relationships in the gut [J].

Hooper, LV ;

Gordon, JI .

SCIENCE, 2001, 292 (5519) :1115-1118

[8]

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine [J].

Ivanov, Ivaylo I. ;

Frutos, Rosa de Llanos ;

Manel, Nicolas ;

Yoshinaga, Keiji ;

Rifkin, Daniel B. ;

Sartor, R. Balfour ;

Finlay, B. Brett ;

Littman, Dan R. .

CELL HOST & MICROBE, 2008, 4 (04) :337-349

[9]

The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells [J].

Ivanov, Ivaylo I. ;

McKenzie, Brent S. ;

Zhou, Liang ;

Tadokoro, Carlos E. ;

Lepelley, Alice ;

Lafaille, Juan J. ;

Cua, Daniel J. ;

Littman, Dan R. .

CELL, 2006, 126 (06) :1121-1133

[10]

Evolution of mammals and their gut microbes [J].

Ley, Ruth E. ;

Hamady, Micah ;

Lozupone, Catherine ;

Turnbaugh, Peter J. ;

Ramey, Rob Roy ;

Bircher, J. Stephen ;

Schlegel, Michael L. ;

Tucker, Tammy A. ;

Schrenzel, Mark D. ;

Knight, Rob ;

Gordon, Jeffrey I. .

SCIENCE, 2008, 320 (5883) :1647-1651