Analgesic effect of sinomenine in rodents after inflammation and nerve injury

被引：132

作者：

Gao, Tianle ^{[1
]}

Hao, Jingxia ^{[1
]}

Wiesenfeld-Hallin, Zsuzsanna ^{[1
]}

Wang, Dan-Qiao ^{[2
]}

Xu, Xiao-Jun ^{[1
]}

机构：

[1] Karolinska Inst, Dept Physiol & Pharmacol, Sect Integrat Pain Res, Stockholm, Sweden

[2] China Acad Chinese Med Sci, Expt Res Ctr, Beijing, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2013年 / 721卷 / 1-3期

关键词：

Analgesia; Herbal medicine; Morphine; Neuropathic pain; Sinomenine; NEUROPATHIC PAIN; GRADING SYSTEM; INHIBITION; ACTIVATION; ARTHRITIS; RECEPTOR; RATS; ALLODYNIA; METHADONE; ISCHEMIA;

D O I：

10.1016/j.ejphar.2013.09.062

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Sinomenine is an alkaloid originally isolated from the root of the plant Sinomenium acutum. It is used in traditional medicine in China to treat rheumatic arthritis. In the present study, we evaluated the potential antinociceptive effects of sinomenine in rodents with nociceptive, inflammatory and neuropathic pain. In normal rats and mice, systemic sinomenine produced moderate antinociceptive effect in the hot plate and tail flick tests. Sinomenine also exerted analgesic effects on mechanical and heat hypersensitivity in mice after carrageenan induced inflammation. Finally, sinomenine effectively alleviated mechanical and cold allodynia in rats and mice after injury to peripheral nerve or spinal cord. The analgesic effect of sinomenine is not associated with side effects and is not reversed by the opioid receptor antagonist naloxone. Our results showed that sinomenine has a wide spectrum analgesic effect in rodent models of nociceptive, inflammatory and neuropathic pain. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：5 / 11

页数：7

共 37 条

[1]

[Anonymous], 2012, Bloomberg News

[2]

Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment [J].

Breivik, H ;

Collett, B ;

Ventafridda, V ;

Cohen, R ;

Gallacher, D .

EUROPEAN JOURNAL OF PAIN, 2006, 10 (04) :287-333

[3]

Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan [J].

Bulka, A ;

Wiesenfeld-Hallin, Z ;

Xu, XJ .

BRAIN RESEARCH, 2002, 942 (1-2) :95-100

[4]

Reduced tolerance to the anti-hyperalgesic effect of methadone in comparison to morphine in a rat model of mononeuropathy [J].

Bulka, A ;

Plesan, A ;

Xu, XJ ;

Wiesenfeld-Hallin, Z .

PAIN, 2002, 95 (1-2) :103-109

[5]

Chen F.J., 2008, J GUANGZHOU U TCM, V25, P421

[6]

Chen Wei, 2004, Zhongguo Zhongyao Zazhi, V29, P900

[7]

Immunoregulatory effects of sinomenine on the T-bet/GATA-3 ratio and Th1/Th2 cytokine balance in the treatment of mesangial proliferative nephritis [J].

Cheng, Yue ;

Zhang, Jingbo ;

Hou, Weiping ;

Wang, Daihong ;

Li, Furong ;

Zhang, Yaoquan ;

Yuan, Fahuan .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2009, 9 (7-8) :894-899

[8]

Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain [J].

Gao, Xiu ;

Kim, Hee Kee ;

Chung, Jin Mo ;

Chung, Kyungsoon .

PAIN, 2007, 131 (03) :262-271

[9]

Revised Definition of Neuropathic Pain and Its Grading System: An Open Case Series Illustrating Its Use in Clinical Practice [J].

Geber, Christian ;

Baumgaertner, Ulf ;

Schwab, Rainer ;

Mueller, Harald ;

Stoeter, Peter ;

Dieterich, Marianne ;

Sommer, Clemens ;

Birklein, Frank ;

Treede, Rolf-Detlef .

AMERICAN JOURNAL OF MEDICINE, 2009, 122 (10) :S3-S12

[10]

Increase in Reactive Oxygen Species and Activation of Akt Signaling Pathway in Neuropathic Pain [J].

Guedes, Renata P. ;

Araujo, Alex S. R. ;

Janner, Daiane ;

Bello-Klein, Adriane ;

Ribeiro, Maria Flavia M. ;

Partata, Wania A. .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2008, 28 (08) :1049-1056

← 1 2 3 4 →