Neutrophils at work

被引：703

作者：

Nauseef, William M. ^{[1
,2
]}

Borregaard, Niels ^{[3
]}

机构：

[1] Univ Iowa, Dept Med, Roy J & Lucille A Carver Coll Med, Inflammat Program, Iowa City, IA 52242 USA

[2] Vet Adm Med Ctr, Iowa City, IA USA

[3] Univ Copenhagen, Natl Univ Hosp, Dept Hematol, Granulocyte Res Lab, Copenhagen, Denmark

来源：

NATURE IMMUNOLOGY | 2014年 / 15卷 / 07期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

EXTRACELLULAR TRAPS MEDIATE; NADPH OXIDASE; POLYMORPHONUCLEAR NEUTROPHILS; LEUKOCYTE ADHESION; PROTON CHANNELS; DENDRITIC CELLS; BONE-MARROW; SUPEROXIDE-PRODUCTION; IMMUNE-RESPONSE; VENULAR WALLS;

D O I：

10.1038/ni.2921

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this Review we discuss data demonstrating recently recognized aspects of neutrophil homeostasis in the steady state, granulopoiesis in 'emergency' conditions and interactions of neutrophils with the adaptive immune system. We explore in vivo observations of the recruitment of neutrophils from blood to tissues in models of blood-borne infections versus bacterial invasion through epithelial linings. We examine data on novel aspects of the activation of NADPH oxidase and the heterogeneity of phagosomes and, finally, consider the importance of two neutrophil-derived biological agents: neutrophil extracellular traps and ectosomes.

引用

页码：602 / 611

页数：10

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