Polycyclic polyprenylated acylphloroglucinols

被引：510

作者：

Ciochina, Roxana ^{[1
]}

Grossman, Robert B. ^{[1
]}

机构：

[1] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 09期

关键词：

D O I：

10.1021/cr0500582

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The plant family Guttiferae comprises a large number of widely distributed species. The antidepressant activity of one such species Hypericum perforatum has generated interest in the metabolites from this family. Over 100 biologically active polycyclic polyprenylated acylphloroglucinols (PPAPs) in either or both enantiomeric forms have been isolated from Guttiferae plants in the past few decades. These compounds share highly oxygenated and densely substituted bicyclo[3.3.1]nonane-2,4,6-trione core adorned with prenyl or geranyl side chains. This review covers the structure and chemical synthesis of PPAPs. Topics discussed include the biological activity of PPAPs, biosynthesis of PPAPs and synthetic efforts toward PPAPs.

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页码：3963 / 3986

页数：24

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