Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens

被引：122

作者：

Flisser, A

Gauci, CG

Zoli, A

Martinez-Ocaña, J

Garza-Rodriguez, A

Dominguez-Alpizar, JL

Maravilla, P

Rodriguez-Canul, R

Avila, G

Aguilar-Vega, L

Kyngdon, C

Geerts, S

Lightowlers, MW

机构：

[1] Univ Melbourne, Ctr Vet Clin, Werribee, Vic 3030, Australia

[2] Univ Dschang, Fac Agr, Dept Anim Prod, Taeniasis Cysticercosis Project, Dschang, Cameroon

[3] Prins Leopold Inst Trop Geneeskunde, Antwerp, Belgium

[4] Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Mexico City, DF, Mexico

[5] Fac Med Vet, Merida, Yucatan, Mexico

[6] CINVESTAV, Merida, Yucatan, Mexico

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 09期

关键词：

D O I：

10.1128/IAI.72.9.5292-5297.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two recombinant Taenia solium oncosphere antigens, designated TSOL18 and TSOL45-1A, were investigated as vaccines to prevent transmission of the zoonotic disease cysticercosis through pigs. Both antigens were effective in inducing very high levels of protection (up to 100%) in three independent vaccine trials in pigs against experimental challenge infection with T. solium eggs, which were undertaken in Mexico and Cameroon. This is the highest level of protection that has been achieved against T. solium infection in pigs by vaccination with a defined antigen. TSOL18 and TSOL45-1A provide the basis for development of a highly effective practical vaccine that could assist in the control and, potentially, the eradication of human neurocysticercosis.

引用

页码：5292 / 5297

页数：6

共 39 条

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