miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets

被引：86

作者：

Klinge, Carolyn M. ^{[1
]}

机构：

[1] Univ Louisville, Sch Med, Dept Biochem & Mol Biol, Ctr Genet & Mol Med, Louisville, KY 40292 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2015年 / 418卷

关键词：

Estrogen; Estrogen receptor; miRNA; Tamoxifen; Transcription mRNA stability; Dicer; Drosha; Endocrine-resistance; Endocrine disrupting chemical; HUMAN BREAST-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; NUCLEAR RECEPTOR COREPRESSOR; NITRIC-OXIDE SYNTHASE; GENOME-WIDE ANALYSIS; ER-ALPHA; DOWN-REGULATION; CELL-PROLIFERATION; POSTTRANSCRIPTIONAL REGULATION; MICRORNA EXPRESSION;

D O I：

10.1016/j.mce.2015.01.035

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are short (22 nucleotides), single-stranded, non-coding RNAs that form complimentary base-pairs with the 3' untranslated region of target mRNAs within the RNA-induced silencing complex (RISC) and block translation and/or stimulate mRNA transcript degradation. The non-coding miRBase (release 21, June 2014) reports that human genome contains similar to 2588 mature miRNAs which regulate similar to 60% of human protein-coding mRNAs. Dysregulation of miRNA expression has been implicated in estrogen-related diseases including breast cancer and endometrial cancer. The mechanism for estrogen regulation of miRNA expression and the role of estrogen-regulated miRNAs in normal homeostasis, reproduction, lactation, and in cancer is an area of great research and clinical interest. Estrogens regulate miRNA transcription through estrogen receptors a and 13 in a tissue-specific and cell-dependent manner. This review focuses primarily on the regulation of miRNA expression by ligand-activated ERs and their bona fide gene targets and includes miRNA regulation by tamoxifen and endocrine disrupting chemicals (EDCs) in breast cancer and cell lines. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：273 / 297

页数：25

共 306 条

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