The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production

被引：47

作者：

Gorosito Serran, Melisa ^{[1
]}

Fiocca Vernengo, Facundo ^{[1
]}

Beccaria, Cristian G. ^{[1
]}

Acosta Rodriguez, Eva V. ^{[1
]}

Montes, Carolina L. ^{[1
]}

Gruppi, Adriana ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Ctr Invest Bioquim Clin & Inmunol, RA-5000 Cordoba, Argentina

来源：

FEBS LETTERS | 2015年 / 589卷 / 22期

关键词：

Regulatory B cell (B reg); Immunoregulation; ALLERGIC AIRWAY INFLAMMATION; CD4(+) T-CELLS; B10; CELLS; IMMUNE-RESPONSES; PROTECTS MICE; SUPPRESSION; ADENOSINE; EXPRESSION; RECEPTOR; INTERLEUKIN-10;

D O I：

10.1016/j.febslet.2015.08.048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The term regulatory B cells (B regs) is ascribed to a heterogeneous population of B cells with the function of suppressing inflammatory responses. They have been described mainly during the last decade in the context of different immune-mediated diseases. Most of the work on B regs has been focused on IL-10-producing B cells. However, B cells can exert regulatory functions independently of IL-10 production. Here we discuss the phenotypes, development and effector mechanisms of B regs and advances in their role in autoimmunity, infections and cancer. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3362 / 3369

页数：8

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