Dairy products and risk of hepatocellular carcinoma: The European Prospective Investigation into Cancer and Nutrition

被引：62

作者：

Duarte-Salles, Talita ^{[1
]}

Fedirko, Veronika ^{[2
,3
]}

Stepien, Magdalena ^{[1
]}

Trichopoulou, Antonia ^{[4
,5
]}

Bamia, Christina ^{[4
]}

Lagiou, Pagona ^{[4
,6
,7
]}

Lukanova, Annekatrin ^{[8
,9
]}

Trepo, Elisabeth ^{[10
]}

Overvad, Kim ^{[11
]}

Tjonneland, Anne ^{[12
]}

Halkjaer, Jytte ^{[12
]}

Boutron-Ruault, Marie-Christine ^{[13
,14
,15
]}

Racine, Antoine ^{[13
,14
,15
]}

Cadeau, Claire ^{[13
,14
,15
]}

Kuehn, Tilman ^{[8
]}

Aleksandrova, Krasimira ^{[16
]}

Trichopoulos, Dimitrios ^{[5
,6
,7
]}

Tsiotas, Konstantinos ^{[4
]}

Boffetta, Paolo ^{[5
,17
]}

Palli, Domenico ^{[18
]}

Pala, Valeria ^{[19
]}

Tumino, Rosario ^{[20
]}

Sacerdote, Carlotta ^{[21
,22
]}

Panico, Salvatore ^{[23
]}

Bueno-de-Mesquita, H. B ^{[24
,25
,26
]}

Dik, Vincent K. ^{[25
]}

Peeters, Petra H. ^{[26
,27
]}

Weiderpass, Elisabete ^{[28
,29
,30
,31
]}

Gram, Inger Torhild ^{[28
]}

Hjartaker, Anette ^{[32
]}

Ramon Quiros, Jose ^{[33
]}

Fonseca-Nunes, Ana ^{[34
]}

Molina-Montes, Esther ^{[35
,36
,37
]}

Dorronsoro, Miren ^{[38
,39
]}

Navarro Sanchez, Carmen ^{[35
,40
,41
]}

Barricarte, Aurelio ^{[35
,42
]}

Lindkvist, Bjorn ^{[43
]}

Sonestedt, Emily ^{[44
]}

Johansson, Ingegerd ^{[45
]}

Wennberg, Maria ^{[46
]}

Khaw, Kay-Tee ^{[47
]}

Wareham, Nick ^{[48
]}

Travis, Ruth C. ^{[49
]}

Romieu, Isabelle ^{[1
]}

Riboli, Elio ^{[26
]}

Jenab, Mazda ^{[1
]}

机构：

[1] IARC, WHO, F-69372 Lyon, France

[2] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[3] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

[4] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[5] Hellenic Hlth Fdn, Athens, Greece

[6] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[7] Acad Athens, Bur Epidemiol Res, Athens, Greece

[8] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[9] Umea Univ, Dept Med Biosci, Umea, Sweden

[10] Ctr Biol Republ, Lyon, France

[11] Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark

[12] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[13] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Nutr Hormones & Womens Hlth Team, U1018, F-94805 Villejuif, France

[14] Univ Paris 11, UMRS 1018, F-94805 Villejuif, France

[15] IGR, F-94805 Villejuif, France

[16] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[17] Icahn Sch Med, Tisch Canc Inst & Inst Translat Epidemiol, New York, NY USA

[18] ISPO, Mol & Nutr Epidemiol Unit, Canc Res & Prevent Inst, Florence, Italy

[19] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[20] ASP Ragusa, Civ M P Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[21] Univ Turin, Canc Epidemiol Unit, AO Citta Salute & Sci, Turin, Italy

[22] Human Genet Fdn HuGeF, Turin, Italy

[23] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[24] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[25] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[26] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, Sch Publ Hlth, Fac Med, London, England

[27] Univ Med Ctr Utrecht, Julius Ctr, Utrecht, Netherlands

[28] UiT Arctic Univ Norway, Dept Community Med, Fac Hlth Sci, Tromso, Norway

[29] Canc Registry Norway, Dept Res, Oslo, Norway

[30] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[31] Samfundet Folkhalsan, Helsinki, Finland

[32] Univ Oslo, Dept Nutr, Oslo, Norway

[33] Publ Hlth Directorate, Asturias, Spain

[34] ICO IDIBELL, Unit Nutr Environm & Canc, Catalan Inst Oncol, Lhospitalet De Llobregat, Spain

[35] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain

[36] Escuela Andaluza Salud Publ, Granada, Spain

[37] Inst Invest Biosanitaria Granada Granada Bs, Granada, Spain

[38] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[39] CIBERESP BIODONOSTIA, San Sebastian, Spain

[40] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[41] Univ Murcia, Dept Hlth & Social Sci, E-30001 Murcia, Spain

[42] Navarre Publ Hlth Inst, Pamplona, Spain

[43] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden

[44] Lund Univ, Dept Clin Sci Malmo, Lund, Sweden

[45] Umea Univ, Dept Odontol, Umea, Sweden

[46] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[47] Univ Cambridge, Sch Clin Med, Clin Gerontol Unit, Cambridge, England

[48] MRC Epidemiol Unit, Cambridge, England

[49] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2014年 / 135卷 / 07期

基金：

英国惠康基金; 英国医学研究理事会; 欧洲研究理事会;

关键词：

hepatocellular carcinoma; dairy products; calcium; prospective cohort; GROWTH-FACTOR-I; PRIMARY LIVER-CANCER; IGF-I; COLORECTAL-CANCER; EPIC PROJECT; HEPATITIS-B; DIET; METAANALYSIS; IGFBP-3; CALCIUM;

D O I：

10.1002/ijc.28812

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Intake of dairy products has been associated with risk of some cancers, but findings are often inconsistent and information on hepatocellular carcinoma (HCC) risk is limited, particularly from prospective settings. The aim of our study was to investigate the association between consumption of total and specific dairy products (milk/cheese/ yogurt) and their components (calcium/vitamin D/fats/protein), with first incident HCC (N-cases=191) in the European Prospective Investigation into Cancer and Nutrition cohort, including a nested case-control subset (N-cases=122) with the assessment of hepatitis B virus/hepatitis C virus infections status, liver damage and circulating insulin-like growth factor (IGF)-I levels. For cohort analyses, multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% CI. A total of 477,206 participants were followed-up for an average of 11 years (person-years follow-up=5,415,385). In the cohort study, a significant positive HCC risk association was observed for total dairy products (highest vs. lowest tertile, HR=1.66, 95% CI: 1.13-2.43; p(trend)=0.012), milk (HR=1.51, 95% CI: 1.02-2.24; p(trend=)0.049), and cheese (HR=1.56, 95% CI: 1.02-2.38; p(trend)=0.101), but not yogurt (HR=0.94, 95% CI: 0.65-1.35). Dietary calcium, vitamin D, fat and protein from dairy sources were associated with increased HCC risk, whereas the same nutrients from nondairy sources showed inverse or null associations. In the nested case-control study, similar results were observed among hepatitis-free individuals. Results from this large prospective cohort study suggest that higher consumption of dairy products, particularly milk and cheese, may be associated with increased HCC risk. Validation of these findings in other populations is necessary. Potential biologic mechanisms require further exploration. What's new? Currently, the role of dairy product intake in the development of hepatocellular carcinoma (HCC) is unclear. Using detailed data from a large multi-centric prospective cohort, this study investigated the association between consumption of total and specific dairy products with first incident HCC. The study found that higher dairy product consumption, particularly milk and cheese, was associated with increased HCC risk. Dietary calcium, vitamin D, fat and protein did not explain the observed associations. However, higher circulating IGF-I levels may play a role.

引用

页码：1662 / 1672

页数：11

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