High density lipoprotein oxidation: in vitro susceptibility and potential in vivo consequences

被引:94
作者
Francis, GA [1 ]
机构
[1] Univ Alberta, Lipid & Lipoprot Res Grp, Edmonton, AB T6G 2S2, Canada
[2] Univ Alberta, Dept Med, Edmonton, AB T6G 2S2, Canada
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2000年 / 1483卷 / 02期
基金
英国医学研究理事会;
关键词
high density lipoprotein; oxidation; cholesterol; cholesterol efflux; atherosclerosis; cardioprotection; Tangier disease;
D O I
10.1016/S1388-1981(99)00181-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Elevated levels of plasma high density lipoprotein (HDL) are strongly predictive of protection against atherosclerotic vascular disease. HDL particles likely have several beneficial actions in vivo, including the initiation of reverse cholesterol transport. The apparent importance of oxidative modification of low density lipoprotein in atherogenesis raises the question of how oxidative modification of HDL might affect its cardioprotective actions. HDL is readily oxidized using numerous models of lipoprotein oxidation. In vitro evidence suggests oxidation might impair some protective actions, but actually enhance other mechanisms induced by HDL that prevent the accumulation of cholesterol in the artery wall. This article reviews the current literature concerning the relative oxidizability of HDL, the structural changes induced in HDL by oxidation in vitro, and the potential consequences of oxidative modification on the protective actions of HDL in vivo. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:217 / 235
页数:19
相关论文
共 142 条
[1]   FORMATION OF DITYROSINE CROSS-LINKS IN PROTEINS BY OXIDATION OF TYROSINE RESIDUES [J].
AESCHBACH, R ;
AMADO, R ;
NEUKOM, H .
BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 439 (02) :292-301
[2]   PLATELET ACTIVATION BY OXIDATIVELY MODIFIED LOW-DENSITY LIPOPROTEINS [J].
ARDLIE, NG ;
SELLEY, ML ;
SIMONS, LA .
ATHEROSCLEROSIS, 1989, 76 (2-3) :117-124
[3]   High-density lipoprotein from hypercholesterolemic animals has peroxidized lipids and oligomeric apolipoprotein A-I: Its putative role in atherogenesis [J].
Artola, RL ;
Conde, CB ;
Bagatolli, L ;
Pecora, RP ;
Fidelio, GD ;
Kivatinitz, SC .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 239 (02) :570-574
[4]  
ASSMANN G, 1986, PROSPECTIVE CARDIOVA
[5]   Oxidation of low density lipoproteins greatly enhances their association with lipoprotein lipase anchored to endothelial cell matrix [J].
Auerbach, BJ ;
Bisgaier, CL ;
Wolle, J ;
Saxena, U .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (03) :1329-1335
[6]   VITAMIN-E CONTENT AND LOW-DENSITY-LIPOPROTEIN OXIDIZABILITY INDUCED BY FREE-RADICALS [J].
BABIY, AV ;
GEBICKI, JM ;
SULLIVAN, DR .
ATHEROSCLEROSIS, 1990, 81 (03) :175-182
[7]   High density lipoprotein and lipoprotein oxidation [J].
Banka, CL .
CURRENT OPINION IN LIPIDOLOGY, 1996, 7 (03) :139-142
[8]  
BECKMAN JS, 1994, METHOD ENZYMOL, V233, P229
[9]   EXTENSIVE NITRATION OF PROTEIN TYROSINES IN HUMAN ATHEROSCLEROSIS DETECTED BY IMMUNOHISTOCHEMISTRY [J].
BECKMANN, JS ;
YE, YZ ;
ANDERSON, PG ;
CHEN, J ;
ACCAVITTI, MA ;
TARPEY, MM ;
WHITE, CR ;
BECKMAN, JS .
BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1994, 375 (02) :81-88
[10]   The role of oxidized lipoproteins in atherogenesis [J].
Berliner, JA ;
Heinecke, JW .
FREE RADICAL BIOLOGY AND MEDICINE, 1996, 20 (05) :707-727