High density lipoprotein oxidation: in vitro susceptibility and potential in vivo consequences

被引:94
作者
Francis, GA [1 ]
机构
[1] Univ Alberta, Lipid & Lipoprot Res Grp, Edmonton, AB T6G 2S2, Canada
[2] Univ Alberta, Dept Med, Edmonton, AB T6G 2S2, Canada
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2000年 / 1483卷 / 02期
基金
英国医学研究理事会;
关键词
high density lipoprotein; oxidation; cholesterol; cholesterol efflux; atherosclerosis; cardioprotection; Tangier disease;
D O I
10.1016/S1388-1981(99)00181-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Elevated levels of plasma high density lipoprotein (HDL) are strongly predictive of protection against atherosclerotic vascular disease. HDL particles likely have several beneficial actions in vivo, including the initiation of reverse cholesterol transport. The apparent importance of oxidative modification of low density lipoprotein in atherogenesis raises the question of how oxidative modification of HDL might affect its cardioprotective actions. HDL is readily oxidized using numerous models of lipoprotein oxidation. In vitro evidence suggests oxidation might impair some protective actions, but actually enhance other mechanisms induced by HDL that prevent the accumulation of cholesterol in the artery wall. This article reviews the current literature concerning the relative oxidizability of HDL, the structural changes induced in HDL by oxidation in vitro, and the potential consequences of oxidative modification on the protective actions of HDL in vivo. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:217 / 235
页数:19
相关论文
共 142 条
[21]   Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency [J].
Brooks-Wilson, A ;
Marcil, M ;
Clee, SM ;
Zhang, LH ;
Roomp, K ;
van Dam, M ;
Yu, L ;
Brewer, C ;
Collins, JA ;
Molhuizen, HOF ;
Loubser, O ;
Ouelette, BFF ;
Fichter, K ;
Ashbourne-Excoffon, KJD ;
Sensen, CW ;
Scherer, S ;
Mott, S ;
Denis, M ;
Martindale, D ;
Frohlich, J ;
Morgan, K ;
Koop, B ;
Pimstone, S ;
Kastelein, JJP ;
Genest, J ;
Hayden, MR .
NATURE GENETICS, 1999, 22 (04) :336-345
[22]  
BROWN MS, 1980, J BIOL CHEM, V255, P9344
[23]  
BROWN MS, 1975, J BIOL CHEM, V250, P4025
[24]   Rapid reduction and removal of HDL- but not LDL-associated cholesteryl ester hydroperoxides by rat liver perfused in situ [J].
Christison, J ;
Karjalainen, A ;
Brauman, J ;
Bygrave, F ;
Stocker, R .
BIOCHEMICAL JOURNAL, 1996, 314 :739-742
[25]  
CLARK RA, 1975, BLOOD, V45, P161
[26]  
COCKERILL GW, 1995, THROMB VASC BIOL, P1987
[27]   High-density lipoprotein 3 physicochemical modifications induced by interaction with human polymorphonuclear leucocytes affect their ability to remove cholesterol from cells [J].
Cogny, A ;
Atger, V ;
Paul, JL ;
Soni, T ;
Moatti, N .
BIOCHEMICAL JOURNAL, 1996, 314 :285-292
[28]   Oxidative modification of high-density lipoprotein 3 induced by human polymorphonuclear neutrophils - Protective effect of pentoxifylline [J].
Cogny, A ;
Paul, JL ;
Surbled, B ;
Atger, V ;
Lenoble, M ;
Moatti, N .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 259 (1-2) :32-39
[29]   STRUCTURAL-CHANGES OF HIGH-DENSITY-LIPOPROTEIN APOLIPOPROTEINS FOLLOWING INCUBATION WITH HUMAN POLYMORPHONUCLEAR CELLS [J].
COGNY, A ;
PAUL, JL ;
ATGER, V ;
SONI, T ;
MOATTI, N .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 222 (03) :965-973
[30]   Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice [J].
Cyrus, T ;
Witztum, JL ;
Rader, DJ ;
Tangirala, R ;
Fazio, S ;
Linton, MF ;
Funk, CD .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (11) :1597-1604