Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes

被引：12

作者：

Antonopoulos, Christina ^{[1
]}

Dubyak, George R. ^{[1
,2
,3
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Sch Med, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期

关键词：

inflammasome; caspase-8; caspase-1; IL-1; beta; chemotherapy; ripoptosome; NLRP3; INFLAMMASOME; ACTIVATION; RELEASE; APOPTOSIS; CELLS;

D O I：

10.4161/onci.27499

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Interleukin-1 beta (IL-1 beta) can limit tumor growth by promoting T cell-mediated antitumor immune responses. Several chemotherapeutic agents can stimulate the production of IL-1 beta by tumor-infiltrating leukocytes via the NLRP3 inflammasome. We have recently demonstrated that some chemotherapeutics can also trigger the secretion of IL-1 beta by driving the assembly of the caspase-8- and FADD-containing platform known as the ripoptosome.

引用

页数：3

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