Ontogeny of the behavioral response to dopamine agonists after chronic cocaine

被引:24
作者
Bowman, BP
Blatt, B
Kuhn, CM
机构
[1] Department of Pharmacology, Duke University Medical Center, Box 3813, Durham
关键词
ontogeny; locomotor behavior; cocaine; dopamine; SKF-38393; quinpirole;
D O I
10.1007/s002130050171
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The behavioral response to separate and combined administration of dopamine D-1 and D-2 receptor agonists was assessed acutely and after chronic cocaine exposure (30 mg/kg SC b.i.d. for 5 days) in infant (PND11) and weanling (PND20) rats. In infants, quinpirole (quin) and SKF-38393 (SKF) elevated locomotion, mouthing and sniffing acutely. Rearing was increased and mouthing decreased by combined administration. In weanlings, quin increased locomotion, mouthing and sniffing in weanlings, while SKF increased only mouthing. SKF inhibited quin-induced rearing and locomotion. Infants treated chronically with cocaine showed sensitized quin- and quin/SKF-induced locomotion and quin/SKF stimulated rearing and sniffing. In weanlings, locomotion was sensitized with all drug combinations, and rearing with SKF alone. These results indicate a developmental progression in the psychopharmacological response to dopamine receptor stimulation. While both D-1 and D-2 receptors are active in infants, the full complement of acute responses and complete capacity for sensitization develop later.
引用
收藏
页码:121 / 127
页数:7
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