The Roles of Notch Signaling in Liver Development and Disease

被引：111

作者：

Adams, Joshua M. ^{[1
,2
,3
]}

Jafar-Nejad, Hamed ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, Med Scientist Training Program, Houston, TX 77030 USA

来源：

BIOMOLECULES | 2019年 / 9卷 / 10期

基金：

美国国家卫生研究院;

关键词：

notch signaling; liver; biliary development; liver fibrosis; liver regeneration; Alagille syndrome; genetic modifiers; liver metabolism; INTRAHEPATIC BILE-DUCTS; ALAGILLE-SYNDROME; MOUSE MODEL; INSULIN-RESISTANCE; MONOZYGOTIC TWINS; HUMAN JAGGED1; RAT-LIVER; PATHWAY; FRINGE; CELLS;

D O I：

10.3390/biom9100608

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Notch signaling pathway plays major roles in organ development across animal species. In the mammalian liver, Notch has been found critical in development, regeneration and disease. In this review, we highlight the major advances in our understanding of the role of Notch activity in proper liver development and function. Specifically, we discuss the latest discoveries on how Notch, in conjunction with other signaling pathways, aids in proper liver development, regeneration and repair. In addition, we review the latest in the role of Notch signaling in the pathogenesis of liver fibrosis and chronic liver disease. Finally, recent evidence has shed light on the emerging connection between Notch signaling and glucose and lipid metabolism. We hope that highlighting the major advances in the roles of Notch signaling in the liver will stimulate further research in this exciting field and generate additional ideas for therapeutic manipulation of the Notch pathway in liver diseases.

引用

页数：20

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