CRF system recruitment mediates dark side of compulsive eating

被引：152

作者：

Cottone, Pietro ^{[1
,2
,3
,5
]}

Sabino, Valentina ^{[1
,2
,3
,5
]}

Roberto, Marisa ^{[1
,2
,3
]}

Bajo, Michal ^{[4
]}

Pockros, Lara ^{[1
]}

Frihauf, Jennifer B. ^{[1
,2
,3
,6
]}

Fekete, Eva M. ^{[1
,2
,3
]}

Steardo, Luca ^{[7
]}

Rice, Kenner C. ^{[8
,9
]}

Grigoriadis, Dimitri E. ^{[10
]}

Conti, Bruno ^{[3
,4
]}

Koob, George F. ^{[1
,2
]}

Zorrilla, Eric P. ^{[1
,2
,3
]}

机构：

[1] Scripps Res Inst, Comm Neurobiol Addict Disorders, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Pearson Ctr Alcoholism & Addict Res, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Harold L Dorris Neurol Res Inst, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Dept Mol & Integrat Neurosci, La Jolla, CA 92037 USA

[5] Boston Univ, Sch Med, Lab Addict Disorders, Dept Pharmacol & Expt Therapeut, Boston, MA 02118 USA

[6] Univ Calif San Diego, Grad Program Neurosci, La Jolla, CA 92093 USA

[7] Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, I-00185 Rome, Italy

[8] Natl Inst Drug Abuse, Chem Biol Res Branch, Bethesda, MD 20892 USA

[9] Natl Inst Alcohol & Alcoholism, Bethesda, MD 20892 USA

[10] Neurocrine Biosci Inc, San Diego, CA 92130 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 47期

关键词：

eating disorders; obesity; palatability; palatable food dependence; withdrawal; CENTRAL AMYGDALA; LIMITED ACCESS; MODEL; RATS; IMMUNOREACTIVITY; PARAMETERS; WITHDRAWAL; INCREASES; CONTRAST;

D O I：

10.1073/pnas.0908789106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dieting to control body weight involves cycles of deprivation from palatable food that can promote compulsive eating. The present study shows that rats withdrawn from intermittent access to palatable food exhibit overeating of palatable food upon renewed access and an affective withdrawal-like state characterized by corticotropin-releasing factor-1 (CRF1) receptor antagonist-reversible behaviors, including hypophagia, motivational deficits to obtain less palatable food, and anxiogenic-like behavior. Withdrawal was accompanied by increased CRF expression and CRF1 electrophysiological responsiveness in the central nucleus of the amygdala. We propose that recruitment of anti-reward extrahy-pothalamic CRF-CRF1 systems during withdrawal from palatable food, analogous to abstinence from abused drugs, may promote compulsive selection of palatable food, undereating of healthier alternatives, and a negative emotional state when intake of palatable food is prevented.

引用

页码：20016 / 20020

页数：5

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