How does the plasma membrane participate in cellular signaling by receptors for immunoglobulin E?

被引：67

作者：

Baird, B ^{[1
]}

Sheets, ED ^{[1
]}

Holowka, D ^{[1
]}

机构：

[1] Cornell Univ, Dept Chem & Biol Chem, Ithaca, NY 14853 USA

来源：

BIOPHYSICAL CHEMISTRY | 1999年 / 82卷 / 2-3期

关键词：

IgE receptor; membrane domains; lipid rafts; signal transduction; lipid-protein interactions; lipid-lipid interactions;

D O I：

10.1016/S0301-4622(99)00110-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulating evidence strongly supports the view that the plasma membrane participates in transmembrane signaling by IgE-receptors (IgE-Fc epsilon RI) through the formation of lipid-based domains, also known as rafts. Ongoing biochemical and biophysical experiments investigate the composition, structure, and dynamics of the corresponding membrane components and how these are related to functional coupling between Fc epsilon RI and Lyn tyrosine kinase to initiate signaling in mast cells. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：109 / 119

页数：11

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