Early Prediction of Sepsis Incidence in Critically Ill Patients Using Specific Genetic Polymorphisms

被引：34

作者：

David, Vlad Laurentiu ^{[1
]}

Ercisli, Muhammed Furkan ^{[2
]}

Rogobete, Alexandru Florin ^{[1
,3
]}

Boia, Eugen S. ^{[1
]}

Horhat, Razvan ^{[1
]}

Nitu, Razvan ^{[1
]}

Diaconu, Mircea M. ^{[1
]}

Pirtea, Laurentiu ^{[1
]}

Ciuca, Ioana ^{[1
]}

Horhat, Delia ^{[1
]}

Horhat, Florin George ^{[1
]}

Licker, Monica ^{[1
]}

Popovici, Sonia Elena ^{[2
]}

Tanasescu, Sonia ^{[1
]}

Tataru, Calin ^{[4
]}

机构：

[1] Victor Babes Univ Med & Pharm, Fac Med, Timisoara, Romania

[2] Ataturk Univ, Fac Med, Erzurum, Turkey

[3] Emergency Cty Hosp Pius Brinzeu, Clin Anesthesia & Intens Care, Timisoara, Romania

[4] Carol Davila Univ Med & Pharm, Fac Med, Bucharest, Romania

来源：

BIOCHEMICAL GENETICS | 2017年 / 55卷 / 03期

关键词：

miRNAs; Biomarkers; Genetic polymorphisms; Sepsis; Critically ill patients; TNF-ALPHA; KAPPA-B; MORTALITY; INTERLEUKIN-10; SUSCEPTIBILITY; ASSOCIATION; BIOMARKERS; INFECTION; VARIANTS; OUTCOMES;

D O I：

10.1007/s10528-016-9785-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Several diagnostic methods for the evaluation and monitoring were used to find out the pro-inflammatory status, as well as incidence of sepsis in critically ill patients. One such recent method is based on investigating the genetic polymorphisms and determining the molecular and genetic links between them, as well as other sepsis-associated pathophysiologies. Identification of genetic polymorphisms in critical patients with sepsis can become a revolutionary method for evaluating and monitoring these patients. Similarly, the complications, as well as the high costs associated with the management of patients with sepsis, can be significantly reduced by early initiation of intensive care.

引用

页码：193 / 203

页数：11

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