Outcomes in meningitis/ventriculitis treated with intravenous or intraventricular plus intravenous colistin

被引：46

作者：

Fotakopoulos, George ^{[1
]}

Makris, Demosthenes ^{[2
]}

Chatzi, Maria ^{[2
]}

Tsimitrea, Eleni ^{[2
]}

Zakynthinos, Epaminondas ^{[2
]}

Fountas, Kostas ^{[1
]}

机构：

[1] Univ Hosp Larissa, Univ Hosp Thessaly, Dept Neurosurg, Larisa 41110, Thessaly, Greece

[2] Univ Thessaly, Univ Hosp Larissa, Dept Head Crit Care, Larisa 41110, Thessaly, Greece

来源：

ACTA NEUROCHIRURGICA | 2016年 / 158卷 / 03期

关键词：

Nosocomial meningitis/ventriculitis; Intrathecal/intraventricular colistin treatment; CNS infections; RESISTANT ACINETOBACTER-BAUMANNII; NERVOUS-SYSTEM INFECTIONS; MULTIDRUG-RESISTANT; INTRATHECAL COLISTIN; CASE SERIES; MENINGITIS; VENTRICULITIS; DRUG; METHANESULFONATE; MANAGEMENT;

D O I：

10.1007/s00701-016-2702-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this work is to evaluate the outcome of patients treated with intrathecal colistin for meningitis/ventriculitis. This retrospective case series study included patients presenting with nosocomial meningitis/ventriculitis following neurosurgical interventions and having intravenous (IVC group) or intravenous and intrathecal/intraventricular colistin (ITC group) treatment between 2006 and 2014. Thirty-four patients presented nosocomial meningitis/ventriculitis; 11 (32.5 %) were included in the IVC group and 23 (67.6 %) in the ITC group. The most frequent isolated bacteria were Acinetobacter baumannii. The mean dose was 170,000 (+/- 400) IU and the duration of intraventricular treatment was 16.0 (+/- 8.3) days. The duration of intravenous treatment was 16.0 (+/- 8.3) days in the ITC group and 15.3 +/- 7.6 days in IVC group. Hospital mortality was significantly lower in the ITC group compared with the IVC group (13 vs. 72.7 %, p = 0.001). The combination of intravenous plus intraventricular (IV-IVT) colistin therapy may improve outcomes in patients attending with meningitis/ventriculitis due to multi-drug resistance infections.

引用

页码：603 / 610

页数：8

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