Intrathecal/intraventricular colistin in external ventricular device-related infections by multi-drug resistant Gram negative bacteria: case reports and review

被引：33

作者：

Bargiacchi, O. ^{[1
]}

Rossati, A. ^{[1
]}

Car, P. ^{[2
]}

Brustia, D. ^{[1
]}

Brondolo, R. ^{[1
]}

Rosa, F. ^{[1
]}

Garavelli, P. L. ^{[1
]}

De Rosa, F. G. ^{[3
]}

机构：

[1] Univ Hosp Maggiore Carita, Dept Infect Dis, Novara, Italy

[2] Univ Hosp Maggiore Carita, Dept Neurosurg, Novara, Italy

[3] Univ Turin, Dept Med Sci, Turin, Italy

来源：

INFECTION | 2014年 / 42卷 / 05期

关键词：

Intrathecal colistin; Nosocomial meningitis; Ventriculitis; Multidrug resistant Gram-negative infections; ACINETOBACTER-BAUMANNII MENINGITIS; CRITICALLY-ILL PATIENTS; INTRATHECAL COLISTIN; INTRAVENTRICULAR COLISTIN; CEREBROSPINAL-FLUID; CASE SERIES; KLEBSIELLA-PNEUMONIAE; METHANESULFONATE; COMBINATION; MANAGEMENT;

D O I：

10.1007/s15010-014-0618-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report three cases of external ventricular derivation infections caused by multidrug-resistant Gram-negative rods and treated successfully with intraventricular colistin. The intrathecal or intraventricular use of colistin have been reported in more than 100 cases without any consensus on dosage, duration and type (monotherapy or combination therapy) of treatment. Based on our comprehensive review of the relevant literature relating to both clinical and pharmacokinetic data, we conclude that the intrathecal/intraventricular administration of colistin is a safe and effective option to treat central nervous system infections caused by multidrug-resistant Gram-negative bacteria.

引用

页码：801 / 809

页数：9

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