Versatile signaling through NKG2D

被引:34
作者
Long, EO [1 ]
机构
[1] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA
关键词
D O I
10.1038/ni1202-1119
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Receptors in the immune system usually specialize in transmitting specific types of signals. However, by associating with two different signaling subunits, the receptor NKG2D can transmit distinct signals for either costimulation or full-fledged activation.
引用
收藏
页码:1119 / 1120
页数:2
相关论文
共 12 条
  • [1] Cutting edge: Murine UL16-binding protein-like transcript 1: A newly described transcript encoding a high-affinity ligand for marine NKG2D
    Carayannopoulos, LN
    Naidenko, OV
    Fremont, DH
    Yokoyama, WM
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 169 (08) : 4079 - 4083
  • [2] Natural killer cells, viruses and cancer
    Cerwenka, A
    Lanier, LL
    [J]. NATURE REVIEWS IMMUNOLOGY, 2001, 1 (01) : 41 - 49
  • [3] Chang CW, 1999, J IMMUNOL, V163, P4651
  • [4] Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
    Diefenbach, A
    Tomasello, E
    Lucas, M
    Jamieson, AM
    Hsia, JK
    Vivier, E
    Raulet, DH
    [J]. NATURE IMMUNOLOGY, 2002, 3 (12) : 1142 - 1149
  • [5] NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
    Gilfillan, S
    Ho, EL
    Cella, M
    Yokoyama, WM
    Colonna, M
    [J]. NATURE IMMUNOLOGY, 2002, 3 (12) : 1150 - 1155
  • [6] Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells
    Groh, V
    Rhinehart, R
    Randolph-Habecker, J
    Topp, MS
    Riddell, SR
    Spies, T
    [J]. NATURE IMMUNOLOGY, 2001, 2 (03) : 255 - 260
  • [7] The role of the NKG2D immunoreceptor in immune cell activation and natural killing
    Jamieson, AM
    Diefenbach, A
    McMahon, CW
    Xiong, N
    Carlyle, JR
    Raulet, DH
    [J]. IMMUNITY, 2002, 17 (01) : 19 - 29
  • [8] The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
    Lanier, LL
    Bakker, ABH
    [J]. IMMUNOLOGY TODAY, 2000, 21 (12): : 611 - 614
  • [9] Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in rheumatoid arthritis
    Namekawa, T
    Snyder, MR
    Yen, JH
    Goehring, BE
    Leibson, PJ
    Weyand, CM
    Goronzy, JJ
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (02) : 1138 - 1145
  • [10] UL16-Binding proteins, novel MHC class I-Related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells
    Sutherland, CL
    Chalupny, NJ
    Schooley, K
    VandenBos, T
    Cosman, D
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 168 (02) : 671 - 679