A multicentre study of reference intervals for haemoglobin, basic blood cell counts and erythrocyte indices in the adult population of the Nordic countries

被引:75
作者
Nordin, G
Mårtensson, A
Swolin, B
Sandberg, S
Christensen, NJ
Thorsteinsson, V
Franzson, L
Kairisto, V
Savolainen, ER
机构
[1] EQUALIS AB, SE-75109 Uppsala, Sweden
[2] Sahlgrens Univ Hosp, Dept Clin Chem & Transfus Med, Gothenburg, Sweden
[3] Univ Bergen, Div Gen Practice, NOKLUS, Bergen, Norway
[4] Haukeland Hosp, Lab Clin Biochem, N-5021 Bergen, Norway
[5] Aarhus Univ Hosp, Dept Clin Biochem, DK-8000 Aarhus, Denmark
[6] FSA Hosp, Dept Lab Serv, Akureyri, Iceland
[7] Reykjavik City Hosp, Dept Clin Biochem, Reykjavik, Iceland
[8] Turku Univ Hosp, Lab Dept 931, FIN-20520 Turku, Finland
[9] Univ Oulu, Dept Clin Chem, Oulu Univ Hosp, Oulu, Finland
关键词
haematology; leukocyte count; normal values; platelet count; red blood cell count;
D O I
10.1080/00365510410002797
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Eight haematological quantities were measured in EDTA anticoagulated venous blood specimens collected from 1826 healthy male and female individuals between 18 and 90 years of age in the Nordic countries ( Denmark, Finland, Iceland, Norway and Sweden). The samples, collected between November 1999 and November 2001 as part of the Nordic Reference Interval Project (NORIP), were analysed on 12 different types of modern automated haematology instruments currently in use among the 60 laboratories participating in the study. Non-parametric reference intervals (between 2.5 and 97.5 percentiles) have been calculated for B-Haemoglobin (females 117-153 g/L, males 134-170 g/L), B-Erythrocytes (females 3.94-5.16 x 10(12)/L, males 4.25-5.71 x 10(12)/L), B-EVF (females 0.348-0.459, males 0.395-0.500), B-MCV (82-98 fL), Erc-MCH (27.1-33.3 pg), Erc-MCHC (317-357 g/L), B-Trc (females 165-387 x 10(9)/L, males 145 x 348 x 10(9)/L) and B-Lkc (3.5-8.8 x 10(9)/L). Partitioning of data according to age and gender was done according to a standardized procedure. For most variables the calculated reference intervals corresponded well with older and less well-defined reference intervals. The mean concentration of B-Haemoglobin increased by 0.08 g/L per year of age in women, and decreased by 0.1 g/L per year of age in men. B-Haemoglobin increased with body mass index in both men and women. Smoking increased the mean of B-Lkc by 1.1 x 10(9)/L and regular use of alcohol increased the mean of B-MCV by 0.8 fL. The influence of these factors was small overall and did not promote specific reference intervals.
引用
收藏
页码:385 / 397
页数:13
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