Stem cell transplantation for treatment of severe autoimmune diseases:: current status and future perspectives

被引：14

作者：

Jantunen, E ^{[1
]}

Myllykangas-Luosujärvi, R ^{[1
]}

机构：

[1] Kuopio Univ Hosp, Dept Med, Kuopio 70211, Finland

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 25卷 / 04期

关键词：

stem cell transplantation; autoimmune diseases;

D O I：

10.1038/sj.bmt.1702152

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Autoimmune diseases include a heterogenous group of disorders with variable presentation and severity. Immunosuppressive and immunomodulatory therapies are often used for treatment with considerable success in some cases. These diseases may also be severe and refractory to conventional treatment. Thus more aggressive intervention might be indicated in a subset of patients. Animal studies suggest that high-dose therapy supported by stem cell transplantation may lead to remissions in experimental autoimmune disease models. Anecdotal case reports suggest that the same may be the case in some human autoimmune diseases as well. This review attempts to summarise some current concepts and future perspectives on stem cell transplantation in the treatment of severe autoimmune diseases.

引用

页码：351 / 356

页数：6

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