Stem cell transplantation for treatment of severe autoimmune diseases:: current status and future perspectives

被引：14

作者：

Jantunen, E ^{[1
]}

Myllykangas-Luosujärvi, R ^{[1
]}

机构：

[1] Kuopio Univ Hosp, Dept Med, Kuopio 70211, Finland

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 25卷 / 04期

关键词：

stem cell transplantation; autoimmune diseases;

D O I：

10.1038/sj.bmt.1702152

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Autoimmune diseases include a heterogenous group of disorders with variable presentation and severity. Immunosuppressive and immunomodulatory therapies are often used for treatment with considerable success in some cases. These diseases may also be severe and refractory to conventional treatment. Thus more aggressive intervention might be indicated in a subset of patients. Animal studies suggest that high-dose therapy supported by stem cell transplantation may lead to remissions in experimental autoimmune disease models. Anecdotal case reports suggest that the same may be the case in some human autoimmune diseases as well. This review attempts to summarise some current concepts and future perspectives on stem cell transplantation in the treatment of severe autoimmune diseases.

引用

收藏

页码：351 / 356

页数：6

相关论文

共 57 条

[41] Autologous PBPCT in a patient with lymphoma and Sjogren's syndrome:: complete remission of lymphoma without control of the autoimmune disease [J].

Rösler, W ;

Manger, B ;

Repp, R ;

Kalden, JR ;

Gramatzki, M .

BONE MARROW TRANSPLANTATION, 1998, 22 (02) :211-213

[42] Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients [J].

Schmitz, N ;

Linch, DC ;

Dreger, P ;

Goldstone, AH ;

Boogaerts, MA ;

Ferrant, A ;

Demuynck, HMS ;

Link, H ;

Zander, A ;

Barge, A ;

Borkett, K .

LANCET, 1996, 347 (8998) :353-357

[43] Autologous peripheral blood stem cell transplantation in a patient with chronic autoimmune thrombocytopenia [J].

Skoda, RC ;

Tichelli, A ;

Tyndall, A ;

Hoffmann, T ;

Gillessen, S ;

Gratwohl, A .

BRITISH JOURNAL OF HAEMATOLOGY, 1997, 99 (01) :56-57

[44] Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases [J].

Slavin, S ;

Nagler, A ;

Naparstek, E ;

Kapelushnik, Y ;

Aker, M ;

Cividalli, G ;

Varadi, G ;

Kirschbaum, M ;

Ackerstein, A ;

Samuel, S ;

Amar, A ;

Brautbar, C ;

Ben-Tal, O ;

Eldor, A ;

Or, R .

BLOOD, 1998, 91 (03) :756-763

[45] A randomised, blinded, placebo-controlled, dose escalation study of the tolerability and efficacy of filgrastim for haemopoietic stem cell mobilisation in patients with severe active rheumatoid arthritis [J].

Snowden, JA ;

Biggs, JC ;

Milliken, ST ;

Fuller, A ;

Staniforth, D ;

Passuello, F ;

Renwick, J ;

Brooks, PM .

BONE MARROW TRANSPLANTATION, 1998, 22 (11) :1035-1041

[46] Prolonged remission of longstanding systemic lupus erythematosus after autologous bone marrow transplant for non-Hodgkin's lymphoma [J].

Snowden, JA ;

Patton, WN ;

ODonnell, JL ;

Hannah, EE ;

Hart, DNJ .

BONE MARROW TRANSPLANTATION, 1997, 19 (12) :1247-1250

[47]

Snowden JA, 1999, ARTHRITIS RHEUM, V42, P2286, DOI 10.1002/1529-0131(199911)42:11<2286::AID-ANR5>3.0.CO

[48]

2-X

[49] Haemopoietic stem cell transplantation for autoimmune diseases [J].

Snowden, JA ;

Brooks, PM ;

Biggs, JC .

BRITISH JOURNAL OF HAEMATOLOGY, 1997, 99 (01) :9-22

[50] Treatment of systemic sclerosis with autologous haemopoietic stem cell transplantation [J].

Tyndall, A ;

Black, C ;

Finke, J ;

Winkler, J ;

Mertlesmann, R ;

Peter, HH ;

Gratwohl, A .

LANCET, 1997, 349 (9047) :254-254

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