The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis

被引：53

作者：

Genua, Marco ^{[1
]}

Rutella, Sergio ^{[2
]}

Correale, Carmen ^{[1
]}

Danese, Silvio ^{[1
]}

机构：

[1] Humanitas Clin & Res Hosp, IBD Ctr, Rozzano, Italy

[2] Sidra Med & Res Ctr, Res Branch, Div Translat Med, Doha, Qatar

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2014年 / 12卷

关键词：

Inflammatory bowel disease; TREM; Myeloid cells; Bacterial sensing; Inflammation; Innate immunity; CUTTING EDGE; INNATE IMMUNITY; OSTEOCLAST DIFFERENTIATION; PROMOTES SURVIVAL; MOUSE MACROPHAGES; DOMAIN RECEPTORS; SOLUBLE TREM-1; FAMILY-MEMBER; SERUM-LEVELS; ACTIVATION;

D O I：

10.1186/s12967-014-0293-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.

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页数：12

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