Hepatocellular carcinoma pathogenesis: from genes to environment

被引：1655

作者：

Farazi, Paraskevi A.

DePinho, Ronald A.

机构：

[1] Harvard Univ, Dana Farber Canc Inst, Dept Med Oncol, Cambridge, MA 02138 USA

[2] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Genet, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

[5] Harvard Univ, Dept Genet, Div Med Genet, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1934

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human population. Despite its significance, there is only an elemental understanding of the molecular, cellular and environmental mechanisms that drive disease pathogenesis, and there are only limited therapeutic options, many with negligible clinical benefit. This Review summarizes the current state of knowledge of this, the most common and dreaded liver neoplasm, and highlights the principal challenges and scientific opportunities that are relevant to controlling this accelerating global health crisis.

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收藏

页码：674 / 687

页数：14

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