Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels

被引：298

作者：

Annabi, Nasim ^{[1
,2
,3
,4
]}

Shin, Su Ryon ^{[1
,2
,3
]}

Tamayol, Ali ^{[1
,2
,3
]}

Miscuglio, Mario ^{[1
,2
]}

Bakooshli, Mohsen Afshar ^{[1
,2
]}

Assmann, Alexander ^{[1
,2
,3
,5
]}

Mostafalu, Pooria ^{[1
,2
]}

Sun, Jeong-Yun ^{[6
]}

Mithieux, Suzanne ^{[7
]}

Cheung, Louis ^{[8
]}

Tang, Xiaowu ^{[8
]}

Weiss, Anthony S. ^{[7
]}

Khademhosseini, Ali ^{[1
,2
,3
,9
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Biomat Innovat Res Ctr,Dept Med, Cambridge, MA 02139 USA

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[4] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA

[5] Univ Dusseldorf, Dept Cardiovasc Surg, D-40225 Dusseldorf, Germany

[6] Seoul Natl Univ, Dept Mat Sci & Engn, Seoul 151742, South Korea

[7] Univ Sydney, Bosch Inst, Mol Biosci, Charles Perkins Ctr, Sydney, NSW 2006, Australia

[8] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

[9] King Abdulaziz Univ, Dept Phys, Jeddah 21569, Saudi Arabia

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 01期

基金：

英国医学研究理事会; 美国国家科学基金会; 澳大利亚国家健康与医学研究理事会; 澳大利亚研究理事会; 美国国家卫生研究院;

关键词：

GRAPHENE OXIDE; POLYPEPTIDES; TROPOELASTIN; NANOTUBES; STRENGTH; GELATIN;

D O I：

10.1002/adma.201503255

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A highly elastic hybrid hydrogel of methacryloyl-substituted recombinant human tropoelastin (MeTro) and graphene oxide (GO) nanoparticles are developed. The synergistic effect of these two materials signifi cantly enhances both ultimate strain (250%), reversible rotation (9700 degrees), and the fracture energy (38.8 +/- 0.8 J m(-2)) in the hybrid network. Furthermore, improved electrical signal propagation and subsequent contraction of the muscles connected by hybrid hydrogels are observed in ex vivo tests.

引用

页码：40 / +

页数：11

共 58 条

[1]

Highly Elastic Micropatterned Hydrogel for Engineering Functional Cardiac Tissue [J].