TCTP as therapeutic target in cancers

被引：101

作者：

Acunzo, Julie ^{[1
,2
,3
,4
]}

Baylot, Virginie ^{[1
,2
,3
,4
]}

So, Alan ^{[5
]}

Rocchi, Palma ^{[1
,2
,3
,4
]}

机构：

[1] INSERM, U1068, CRCM, F-13009 Marseille, France

[2] Inst J Paoli I Calmettes, F-13009 Marseille, France

[3] Aix Marseille Univ, F-13284 Marseille, France

[4] CNRS, UMR7258, F-13009 Marseille, France

[5] Univ British Columbia, Vancouver, BC V6H 3Z6, Canada

来源：

CANCER TREATMENT REVIEWS | 2014年 / 40卷 / 06期

关键词：

TCTP; Therapeutic target; Cancer; Inhibitory strategy; CONTROLLED TUMOR PROTEIN; HISTAMINE-RELEASING-FACTOR; MESSENGER-RNA; CALCIUM-BINDING; MOLECULAR-IDENTIFICATION; EXPRESSION; KINASE; GROWTH; SECRETION; CELLS;

D O I：

10.1016/j.ctrv.2014.02.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The translationally controlled tumor protein (TCTP) is a highly conserved protein present in eukaryotic organisms. This protein, located both in the cytoplasmic and the nucleus, is expressed in various tissues and is regulated in response to a wide range of extracellular stimuli. TCTP interacts with itself and other protein including MCL1 and p53. TCTP has been shown to play an important role in physiological events, such as cell proliferation, cell death and immune responses but also in stress response and tumor reversion. Moreover, TCTP expression is associated with malignancy and chemoresistance. In this review, we will evaluate pathways regulated by TCTP and current inhibitory strategy to target TCTP in cancerous diseases. (C) 2014 Elsevier Ltd. All rights reserved.

引用

收藏

页码：760 / 769

页数：10

相关论文

共 102 条

[1]

TPT1/ TCTP-regulated pathways in phenotypic reprogramming [J].

Amson, Robert ;

Pece, Salvatore ;

Marine, Jean-Christophe ;

Di Fiore, Pier Paolo ;

Telerman, Adam .

TRENDS IN CELL BIOLOGY, 2013, 23 (01) :37-46

[2]

Reciprocal repression between P53 and TCTP [J].

Amson, Robert ;

Pece, Salvatore ;

Lespagnol, Alexandra ;

Vyas, Rajesh ;

Mazzarol, Giovanni ;

Tosoni, Daniela ;

Colaluca, Ivan ;

Viale, Giuseppe ;

Rodrigues-Ferreira, Sylvie ;

Wynendaele, Jessika ;

Chaloin, Olivier ;

Hoebeke, Johan ;

Marine, Jean-Christophe ;

Di Fiore, Pier Paolo ;

Telerman, Adam .

NATURE MEDICINE, 2012, 18 (01) :91-99

[3]

TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway [J].

Amzallag, N ;

Passer, BJ ;

Allanic, D ;

Segura, E ;

Théry, C ;

Goud, B ;

Amson, R ;

Telerman, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (44) :46104-46112

[4]

Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) is regulated by CREB transcription factors [J].

Andree, Holger ;

Thiele, Holger ;

Faehling, Michael ;

Schmidt, Irina ;

Thiele, Bernd-Joachim .

GENE, 2006, 380 (02) :95-103

[5]

Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: Expression, distribution, and calcium binding activity [J].

Arcuri, F ;

Papa, S ;

Carducci, A ;

Romagnoli, R ;

Liberatori, S ;

Riparbelli, MG ;

Sanchez, JC ;

Tosi, P ;

del Vecchio, MT .

PROSTATE, 2004, 60 (02) :130-140

[6]

The dsRNA-dependent protein kinase, PKR and cell death [J].

Barber, GN .

CELL DEATH AND DIFFERENTIATION, 2005, 12 (06) :563-570

[7]

Baylot V, 2012, MOL THER

[8]

Complex relationship between TCTP, microtubules and actin microfilaments regulates cell shape in normal and cancer cells [J].

Bazile, Franck ;

Pascal, Aude ;

Arnal, Isabelle ;

Le Clainche, Christophe ;

Chesnel, Franck ;

Kubiak, Jacek Z. .

CARCINOGENESIS, 2009, 30 (04) :555-565

[9]

Bheekha-Escura R, 2000, BLOOD, V96, P2191

[10]

Protein expression profiles in human breast ductal carcinoma and histologically normal tissue [J].

Bini, L ;

Magi, B ;

Marzocchi, B ;

Arcuri, F ;

Tripodi, S ;

Cintorino, M ;

Sanchez, JC ;

Frutiger, S ;

Hughes, G ;

Pallini, V ;

Hochstrasser, DF ;

Tosi, P .

ELECTROPHORESIS, 1997, 18 (15) :2832-2841

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